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Early versus later anticoagulation for stroke with atrial fibrillation

In a large trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants.

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Bibliographic Details
Main Authors: Fischer, Urs (Author) , Koga, Masatoshi (Author) , Strbian, Daniel (Author) , Branca, Mattia (Author) , Abend, Stefanie (Author) , Trelle, Sven (Author) , Paciaroni, Maurizio (Author) , Thomalla, Götz (Author) , Michel, Patrik (Author) , Nedeltchev, Krassen (Author) , Bonati, Leo H. (Author) , Gumbinger, Christoph (Author) , Alonso, Angelika (Author)
Format: Article (Journal)
Language:English
Published: June 29, 2023
In: The New England journal of medicine
Year: 2023, Volume: 388, Issue: 26, Pages: 2411-2421
ISSN:1533-4406
DOI:10.1056/NEJMoa2303048
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2303048
Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2303048
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Author Notes:U. Fischer, M. Koga, D. Strbian, M. Branca, S. Abend, S. Trelle, M. Paciaroni, G. Thomalla, P. Michel, K. Nedeltchev, L.H. Bonati, G. Ntaios, T. Gattringer, E.-C. Sandset, P. Kelly, R. Lemmens, P.N. Sylaja, D. Aguiar de Sousa, N.M. Bornstein, Z. Gdovinova, T. Yoshimoto, M. Tiainen, H. Thomas, M. Krishnan, G.C. Shim, C. Gumbinger, J. Vehoff, L. Zhang, K. Matsuzono, E. Kristoffersen, P. Desfontaines, P. Vanacker, A. Alonso, Y. Yakushiji, C. Kulyk, D. Hemelsoet, S. Poli, A. Paiva Nunes, N. Caracciolo, P. Slade, J. Demeestere, A. Salerno, M. Kneihsl, T. Kahles, D. Giudici, K. Tanaka, S. Räty, R. Hidalgo, D.J. Werring, M. Göldlin, M. Arnold, C. Ferrari, S. Beyeler, C. Fung, B.J. Weder, T. Tatlisumak, S. Fenzl, B. Rezny-Kasprzak, A. Hakim, G. Salanti, C. Bassetti, J. Gralla, D.J. Seiffge, T. Horvath, and J. Dawson, for the ELAN Investigators
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Summary:In a large trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants.
Item Description:Online veröffentlicht: May 24, 2023
Gesehen am 08.08.2024
Physical Description:Online Resource
ISSN:1533-4406
DOI:10.1056/NEJMoa2303048

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