Parapapillary gamma zone associated with increased peripapillary scleral bowing: the Beijing Eye Study 2011 : clinical science
Aims To investigate the association between the backward configuration of the peripapillary sclera (PPS), measured as PPS angle (PPSA), and presence and extent of parapapillary gamma zone. - Methods Out of the population-based Beijing Eye Study 2011, we randomly selected individuals free of optic ne...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 20, 2023
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| In: |
British journal of ophthalmology
Year: 2023, Volume: 107, Issue: 11, Pages: 1665-1671 |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjo-2022-321868 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1136/bjo-2022-321868 Verlag, kostenfrei, Volltext: http://bjo.bmj.com/content/107/11/1665 
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| Author Notes: | Can Can Xue, Xiaofei Wang, Ying Xiang Han, Qi Zhang, Chun Zhang, Ya Xing Wang, Jost B. Jonas |
| Summary: | Aims To investigate the association between the backward configuration of the peripapillary sclera (PPS), measured as PPS angle (PPSA), and presence and extent of parapapillary gamma zone. - Methods Out of the population-based Beijing Eye Study 2011, we randomly selected individuals free of optic nerve and retinal diseases. With Spectralis optical coherence tomography, we measured gamma zone (zone free of Bruch’s membrane (BM)) and determined the PPSA, defined as the angle between the anterior scleral surface lines from both sides of the optic nerve head (ONH). - Results The study included 678 individuals with age of 59.5±7.6 years (range: 50-90) and axial length of 23.5±1.3 mm (20.9-29.2). Gamma zone was more prevalent in eyes with larger PPSA (p=0.006) after adjustment for axial length (p<0.001) and BM opening area (p<0.001). Gamma zone width was positively associated with PPSA, axial length and BM opening area (all p<0.001) in multivariable analysis. Circular gamma zone was accompanied with larger PPSA as compared with focal gamma zone (19.9°±7.2° vs 6.3°±5.3°, p<0.001). Focal temporal gamma and focal inferior gamma had similar mean PPSA (p=0.69). However, the horizontal PPSA was significantly larger than the vertical PPSA in inferior gamma (6.9°±6.3° vs 4.7°±6.6°; p=0.005), while they were comparable in temporal gamma (6.1°±5.8° vs 6.3°±6.4°; p=0.073). - Conclusions A more backward bowing of the PPS was linearly and spatially associated with the presence, size and extent of gamma zone. It suggested that the BM and the sclera were closely related in participating the biomechanical behaviour of the ONH. |
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| Item Description: | Erstmals online veröffentlicht: 6. September 2022 Gesehen am 13.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjo-2022-321868 |