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Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries

Lynch syndrome (LS), the most common inherited form of colorectal cancer (CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene defect and is characterized by a high risk for CRC, endometrial cancer and several other cancers. Identification of LS is of utmost import...

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Main Authors: Sina, Mohammad (Author) , Ghorbanoghli, Zeinab (Author) , Abedrabbo, Amal (Author) , Al-Mulla, Fahd (Author) , Sghaier, Rihab Ben (Author) , Buisine, Marie-Pierre (Author) , Cortas, George (Author) , Goshayeshi, Ladan (Author) , Hadjisavvas, Andreas (Author) , Hammoudeh, Wail (Author) , Hamoudi, Waseem (Author) , Jabari, Carol (Author) , Loizidou, Maria A. (Author) , Majidzadeh-A, Keivan (Author) , Marafie, Makia J. (Author) , Muslumov, Gurbankhan (Author) , Rifai, Laila (Author) , Seir, Rania Abu (Author) , Talaat, Suzan M. (Author) , Tunca, Berrin (Author) , Ziada-Bouchaar, Hadia (Author) , Velthuizen, Mary E. (Author) , Sharara, Ala I. (Author) , Ahadova, Aysel (Author) , Georgiou, Demetra (Author) , Vasen, Hans F. A. (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Familial cancer
Year: 2021, Volume: 20, Issue: 3, Pages: 215-221
ISSN:1573-7292
DOI:10.1007/s10689-020-00211-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10689-020-00211-3
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s10689-020-00211-3
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Author Notes:Mohammad Sina, Zeinab Ghorbanoghli, Amal Abedrabbo, Fahd Al-Mulla, Rihab Ben Sghaier, Marie-Pierre Buisine, George Cortas, Ladan Goshayeshi, Andreas Hadjisavvas, Wail Hammoudeh, Waseem Hamoudi, Carol Jabari, Maria A. Loizidou, Keivan Majidzadeh-A, Makia J. Marafie, Gurbankhan Muslumov, Laila Rifai, Rania Abu Seir, Suzan M. Talaat, Berrin Tunca, Hadia Ziada-Bouchaar, Mary E. Velthuizen, Ala I. Sharara, Aysel Ahadova, Demetra Georgiou, Hans F. A. Vasen, on behalf of the Middle East Network on Hereditary Colorectal Cancer (HCCN-ME)
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Summary:Lynch syndrome (LS), the most common inherited form of colorectal cancer (CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene defect and is characterized by a high risk for CRC, endometrial cancer and several other cancers. Identification of LS is of utmost importance because colonoscopic surveillance substantially improves a patient’s prognosis. Recently, a network of physicians in Middle Eastern and North African (ME/NA) countries was established to improve the identification and management of LS families. The aim of the present survey was to evaluate current healthcare for families with LS in this region.
Item Description:"Published online: 24 October 2020".- S. 215
Gesehen am 15.08.2024
Physical Description:Online Resource
ISSN:1573-7292
DOI:10.1007/s10689-020-00211-3

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