Identification and management of Lynch syndrome in the Middle East and North African countries: outcome of a survey in 12 countries

Lynch syndrome (LS), the most common inherited form of colorectal cancer (CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene defect and is characterized by a high risk for CRC, endometrial cancer and several other cancers. Identification of LS is of utmost import...

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Hauptverfasser: Sina, Mohammad (VerfasserIn) , Ghorbanoghli, Zeinab (VerfasserIn) , Abedrabbo, Amal (VerfasserIn) , Al-Mulla, Fahd (VerfasserIn) , Sghaier, Rihab Ben (VerfasserIn) , Buisine, Marie-Pierre (VerfasserIn) , Cortas, George (VerfasserIn) , Goshayeshi, Ladan (VerfasserIn) , Hadjisavvas, Andreas (VerfasserIn) , Hammoudeh, Wail (VerfasserIn) , Hamoudi, Waseem (VerfasserIn) , Jabari, Carol (VerfasserIn) , Loizidou, Maria A. (VerfasserIn) , Majidzadeh-A, Keivan (VerfasserIn) , Marafie, Makia J. (VerfasserIn) , Muslumov, Gurbankhan (VerfasserIn) , Rifai, Laila (VerfasserIn) , Seir, Rania Abu (VerfasserIn) , Talaat, Suzan M. (VerfasserIn) , Tunca, Berrin (VerfasserIn) , Ziada-Bouchaar, Hadia (VerfasserIn) , Velthuizen, Mary E. (VerfasserIn) , Sharara, Ala I. (VerfasserIn) , Ahadova, Aysel (VerfasserIn) , Georgiou, Demetra (VerfasserIn) , Vasen, Hans F. A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2021
In: Familial cancer
Year: 2021, Jahrgang: 20, Heft: 3, Pages: 215-221
ISSN:1573-7292
DOI:10.1007/s10689-020-00211-3
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10689-020-00211-3
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s10689-020-00211-3
Volltext
Verfasserangaben:Mohammad Sina, Zeinab Ghorbanoghli, Amal Abedrabbo, Fahd Al-Mulla, Rihab Ben Sghaier, Marie-Pierre Buisine, George Cortas, Ladan Goshayeshi, Andreas Hadjisavvas, Wail Hammoudeh, Waseem Hamoudi, Carol Jabari, Maria A. Loizidou, Keivan Majidzadeh-A, Makia J. Marafie, Gurbankhan Muslumov, Laila Rifai, Rania Abu Seir, Suzan M. Talaat, Berrin Tunca, Hadia Ziada-Bouchaar, Mary E. Velthuizen, Ala I. Sharara, Aysel Ahadova, Demetra Georgiou, Hans F. A. Vasen, on behalf of the Middle East Network on Hereditary Colorectal Cancer (HCCN-ME)

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520 |a Lynch syndrome (LS), the most common inherited form of colorectal cancer (CRC), is responsible for 3% of all cases of CRC. LS is caused by a mismatch repair gene defect and is characterized by a high risk for CRC, endometrial cancer and several other cancers. Identification of LS is of utmost importance because colonoscopic surveillance substantially improves a patient’s prognosis. Recently, a network of physicians in Middle Eastern and North African (ME/NA) countries was established to improve the identification and management of LS families. The aim of the present survey was to evaluate current healthcare for families with LS in this region. 
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