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Serotonin signaling through lipid membranes

Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release,...

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Main Authors: Kalinichenko, Liubov (Author) , Kornhuber, Johannes (Author) , Sinning, Steffen (Author) , Haase, Jana (Author) , Müller, Christian P. (Author)
Format: Article (Journal)
Language:English
Published: 3 April 2024
In: ACS chemical neuroscience
Year: 2024, Volume: 15, Issue: 7, Pages: 1298-1320
ISSN:1948-7193
DOI:10.1021/acschemneuro.3c00823
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acschemneuro.3c00823
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Author Notes:Liubov S. Kalinichenko, Johannes Kornhuber, Steffen Sinning, Jana Haase, and Christian P. Müller
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Summary:Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to 5-HT signaling in synaptic and extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although the lipid membrane environment is often viewed as fairly stable, emerging research suggests significant functional lipid-protein interactions with many synaptic 5-HT proteins. These protein-lipid interactions extend to almost all the primary lipid classes that form the plasma membrane. Collectively, these lipid classes and lipid-protein interactions affect 5-HT synaptic efficacy at the synapse. The highly dynamic lipid composition of synaptic membranes suggests that these lipids and their interactions with proteins may contribute to the plasticity of the 5-HT synapse. Therefore, this broader protein-lipid model of the 5-HT synapse necessitates a reconsideration of 5-HT’s role in various associated mental disorders.
Item Description:Online veröffentlicht: 18. März 2024
Gesehen am 21.08.2024
Physical Description:Online Resource
ISSN:1948-7193
DOI:10.1021/acschemneuro.3c00823

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