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Classification of Vitamin D status based on Vitamin D metabolism: a randomized controlled trial in hypertensive patients

Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR...

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Main Authors: Zelzer, Sieglinde (Author) , Meinitzer, Andreas (Author) , Enko, Dietmar (Author) , Keppel, Martin H. (Author) , Herrmann, Markus (Author) , Theiler-Schwetz, Verena (Author) , Trummer, Christian (Author) , Schmitt, Lisa (Author) , Tomaschitz, Andreas (Author) , Sadoghi, Patrick (Author) , Dierkes, Jutta (Author) , Pludowski, Pawel (Author) , Zittermann, Armin (Author) , März, Winfried (Author) , Pilz, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 14 March 2024
In: Nutrients
Year: 2024, Volume: 16, Issue: 6, Pages: 1-12
ISSN:2072-6643
DOI:10.3390/nu16060839
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/nu16060839
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6643/16/6/839
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Author Notes:Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Martin H. Keppel, Markus Herrmann, Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Andreas Tomaschitz, Patrick Sadoghi, Jutta Dierkes, Pawel Pludowski, Armin Zittermann, Winfried März and Stefan Pilz
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Summary:Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR), i.e., 24,25(OH)2D divided by 25(OH)D, may indicate high vitamin D requirements and provide additional diagnostic information beyond serum 25(OH)D. We, therefore, evaluated whether the classification of “functional vitamin D deficiency”, i.e., 25(OH)D below 50 nmol/L, 24,25(OH)2D below 3 nmol/L and a VMR of less than 4%, identifies individuals who benefit from vitamin D supplementation. In participants of the Styrian Vitamin D Hypertension trial, a randomized controlled trial (RCT) in 200 hypertensive patients with serum 25(OH)D below 75 nmol/L, who received either 2.800 international units of vitamin D per day or placebo over 8 weeks, 51 participants had functional vitamin D deficiency. In these individuals, there was no treatment effect of vitamin D supplementation on various parameters of bone metabolism and cardiovascular risk except for a significant effect on parathyroid hormone (PTH) and expected changes in vitamin D metabolites. In conclusion, a low vitamin D metabolite profile did not identify individuals who significantly benefit from vitamin D supplementation with regard to bone markers and cardiovascular risk factors. The clinical significance of functional vitamin D deficiency requires further evaluation in large vitamin D RCTs.
Item Description:Gesehen am 22.08.2024
Physical Description:Online Resource
ISSN:2072-6643
DOI:10.3390/nu16060839

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