Decreased alloreactivity after vaccination against hepatitis B
The beneficial effect of blood transfusions on renal allografts disappeared at about the same time when hepatitis B vaccination was introduced in dialysis patients. To determine possible immunosuppressive effects of hepatitis B vaccination, we studied alloreactivity during the course of immunization...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 15, 1995
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| In: |
Transplantation
Year: 1995, Volume: 59, Issue: 9, Pages: 1339-1342 |
| ISSN: | 1534-6080 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/abstract/1995/05150/decreased_alloreactivity_after_vaccination_against.20.aspx
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| Author Notes: | Hans Ruder, Frank Kerling, Volker Daniel, Klaus Korn, Ralf Wassmuth |
| Summary: | The beneficial effect of blood transfusions on renal allografts disappeared at about the same time when hepatitis B vaccination was introduced in dialysis patients. To determine possible immunosuppressive effects of hepatitis B vaccination, we studied alloreactivity during the course of immunization. Fourteen healthy subjects without serological evidence of hepatitis B were routinely immunized against hepatitis B surface antigen. Plasma and mononuclear cells were isolated and frozen before immunization and after vaccination, respectively. Mean alloreactivity measured by [3H]thymidine uptake decreased from 64,772 cpm before immunization to 40,213 cpm after the third immunization. In crossover experiments, cellular modulation and plasma-dependent modulation of alloreactivity were observed. The immunosuppressive effect of plasma taken 4 weeks after the third vaccination correlated (r=0.9) highly significantly (P<0.005) with the anti-hepatitis B surface antigen antibody titer. Taken together, our data strongly suggest that hepatitis B vaccination is capable of reducing allogenic reactivity. |
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| Item Description: | Gesehen am 22.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1534-6080 |