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Biotechnological metabolization system has the potential to improve the predictive ability of the fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio)

The fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio) was developed to assess the acute fish toxicity of chemicals or environmental samples as a replacement for the Acute Fish Test (AFT) with juvenile fish. However, the FET is not yet established in the regulatory context. One r...

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Bibliographic Details
Main Authors: Reichstein, Inska (Author) , Becker, Alischa H. (Author) , Johann, Sarah (Author) , Braunbeck, Thomas (Author) , Schiwy, Sabrina (Author) , Hollert, Henner (Author) , Schiwy, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 04. May 2024
In: Environmental sciences Europe
Year: 2024, Volume: 36, Issue: 1, Pages: 1-15
ISSN:2190-4715
DOI:10.1186/s12302-024-00913-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12302-024-00913-w
Verlag, lizenzpflichtig, Volltext: https://enveurope.springeropen.com/articles/10.1186/s12302-024-00913-w
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Author Notes:Inska S. Reichstein, Alischa H. Becker, Sarah Johann, Thomas Braunbeck, Sabrina Schiwy, Henner Hollert and Andreas Schiwy
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Summary:The fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio) was developed to assess the acute fish toxicity of chemicals or environmental samples as a replacement for the Acute Fish Test (AFT) with juvenile fish. However, the FET is not yet established in the regulatory context. One reason is the (postulated) difference between the biotransformation capacities of embryos and juvenile fish.
Item Description:Gesehen am 06.09.2024
Physical Description:Online Resource
ISSN:2190-4715
DOI:10.1186/s12302-024-00913-w

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