Cover Image

Empagliflozin improves outcomes in patients with heart failure and preserved ejection fraction irrespective of age

Background - Empagliflozin reduces cardiovascular death (CVD) or heart failure (HF) hospitalization (HFH) in patients with HF and preserved ejection fraction. Treatment effects and safety in relation to age have not been studied. - Objectives - The purpose of this study was to evaluate the interplay...

Full description

Saved in:
Bibliographic Details
Main Authors: Böhm, Michael (Author) , Butler, Javed (Author) , Filippatos, Gerasimos (Author) , Ferreira, João Pedro (Author) , Pocock, Stuart J. (Author) , Abdin, Amr (Author) , Mahfoud, Felix (Author) , Brückmann, Martina (Author) , Gollop, Nicholas D. (Author) , Iwata, Tomoko (Author) , Ponikowski, Piotr (Author) , Wanner, Christoph (Author) , Zannad, Faiez (Author) , Packer, Milton (Author) , Anker, Stefan D. (Author)
Format: Article (Journal)
Language:English
Published: 5 July 2022
In: Journal of the American College of Cardiology
Year: 2022, Volume: 80, Issue: 1, Pages: 1-18
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.04.040
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jacc.2022.04.040
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0735109722049373
Get full text
Author Notes:Michael Böhm, Javed Butler, Gerasimos Filippatos, João Pedro Ferreira, Stuart J. Pocock, Amr Abdin, Felix Mahfoud, Martina Brueckmann, Nicholas D. Gollop, Tomoko Iwata, Piotr Ponikowski, Christoph Wanner, Faiez Zannad, Milton Packer, Stefan D. Anker, on behalf of the EMPEROR-Preserved Trial Committees and Investigators
Description
Summary:Background - Empagliflozin reduces cardiovascular death (CVD) or heart failure (HF) hospitalization (HFH) in patients with HF and preserved ejection fraction. Treatment effects and safety in relation to age have not been studied. - Objectives - The purpose of this study was to evaluate the interplay of age and empagliflozin effects in EMPEROR-Preserved (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction). - Methods - We grouped patients (n = 5,988) according to their baseline age (<65 years [n = 1,199], 65-74 years [n = 2,214], 75-79 years [n = 1,276], ≥80 years [n = 1,299]). We explored the influence of age on empagliflozin effects on CVD or HFH (primary outcome), total HFH, rate of decline in estimated glomerular filtration rate, health-related quality of life with the Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score, and frequency of adverse events. - Results - Considering only patients on placebo, the incidence of primary outcomes (P trend = 0.02) and CVD (P trend = 0.003) increased with age. Empagliflozin reduced primary outcomes (P trend = 0.33), first HFH (P trend = 0.22), and first and recurrent HFH (P trend = 0.11) across all age groups with an effect being similar at ≥75 years (P interaction = 0.22) or >80 years (P interaction = 0.51). Empagliflozin improved Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score at week 52 and attenuated the decline of estimated glomerular filtration rate without age interaction (P = 0.48 and P = 0.32, respectively). There were no clinically relevant differences in adverse events between empagliflozin and placebo across the age groups. - Conclusions - Empagliflozin reduced primary outcomes and first and recurrent HFH and improved symptoms across a broad age spectrum. High age was not associated with reduced efficacy or meaningful intolerability. (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction [EMPEROR-Preserved]; NCT0305951)
Item Description:Online verfügbar: 27. Juni 2022, Artikelversion: 27. Juni 2022
Gesehen am 10.09.2024
Physical Description:Online Resource
ISSN:1558-3597
DOI:10.1016/j.jacc.2022.04.040

Similar Items