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The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population - a comparison of two German registries

Objectives: To investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2...

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Main Authors: Hasseli-Fräbel, Rebecca (Author) , Hanses, Frank (Author) , Stecher, Melanie (Author) , Specker, Christof (Author) , Weise, Tobias (Author) , Borgmann, Stefan (Author) , Hasselberger, Martina (Author) , Hertenstein, Bernd (Author) , Hower, Martin (Author) , Hoyer, Bimba F. (Author) , Koll, Carolin (Author) , Krause, Andreas (Author) , von Lilienfeld-Toal, Marie (Author) , Lorenz, Hanns-Martin (Author) , Merle, Uta (Author) , Nunes de Miranda, Susana Marina (Author) , Pletz, Mathias W. (Author) , Regierer, Anne C. (Author) , Richter, Jutta G. (Author) , Rieg, Siegbert (Author) , Roemmele, Christoph (Author) , Ruethrich, Maria M. (Author) , Schmeiser, Tim (Author) , Schulze-Koops, Hendrik (Author) , Strangfeld, Anja (Author) , Vehreschild, Maria J. G. T. (Author) , Voit, Florian (Author) , Voll, Reinhard (Author) , Vehreschild, Jörg Janne (Author) , Müller-Ladner, Ulf (Author) , Pfeil, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 06 March 2024
In: Frontiers in medicine
Year: 2024, Volume: 11, Pages: 1-12
ISSN:2296-858X
DOI:10.3389/fmed.2024.1332716
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2024.1332716
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1332716/full
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Author Notes:Rebecca Hasseli, Frank Hanses, Melanie Stecher, Christof Specker, Tobias Weise, Stefan Borgmann, Martina Hasselberger, Bernd Hertenstein, Martin Hower, Bimba F. Hoyer, Carolin Koll, Andreas Krause, Marie von Lilienfeld-Toal, Hanns-Martin Lorenz, Uta Merle, Susana M. Nunes de Miranda, Mathias W. Pletz, Anne C. Regierer, Jutta G. Richter, Siegbert Rieg, Christoph Roemmele, Maria M. Ruethrich, Tim Schmeiser, Hendrik Schulze-Koops, Anja Strangfeld, Maria J.G.T. Vehreschild, Florian Voit, Reinhard E. Voll, Jörg Janne Vehreschild, Ulf Müller-Ladner and Alexander Pfeil
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Summary:Objectives: To investigate, whether inflammatory rheumatic diseases (IRD) inpatients are at higher risk to develop a severe course of SARS-CoV-2 infections compared to the general population, data from the German COVID-19 registry for IRD patients and data from the Lean European Survey on SARS-CoV-2 (LEOSS) infected patients covering inpatients from the general population with SARS-CoV-2 infections were compared. Methods: 4310 (LEOSS registry) and 1139 cases (IRD registry) were collected in general. Data were matched for age and gender. From both registries, 732 matched inpatients (LEOSS registry: n> = 366 and IRD registry: n = 366) were included for analyses in total. Results: Regarding the COVID-19 associated lethality, no significant difference between both registries was observed. Age > 65°years, chronic obstructive pulmonary disease, diabetes mellitus, rheumatoid arthritis, spondyloarthritis and the use of rituximab were associated with more severe courses of COVID-19. Female gender and the use of tumor necrosis factor-alpha inhibitors (TNF-I) were associated with a better outcome of COVID-19. Conclusion: Inflammatory rheumatic diseases (IRD) patients have the same risk factors for severe COVID-19 regarding comorbidities compared to the general population without any immune-mediated disease or immunomodulation. The use of rituximab was associated with an increased risk for severe COVID-19. On the other hand, the use of TNF-I was associated with less severe COVID-19 compared to the general population, which might indicate a protective effect of TNF-I against severe COVID-19 disease.
Item Description:Gesehen am 11.09.2024
Physical Description:Online Resource
ISSN:2296-858X
DOI:10.3389/fmed.2024.1332716

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