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A stable and replicable neural signature of lifespan adversity in the adult brain

Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiologi...

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Main Authors: Holz, Nathalie E. (Author) , Zabihi, Mariam (Author) , Kia, Seyed Mostafa (Author) , Monninger, Maximillian (Author) , Aggensteiner, Pascal (Author) , Siehl, Sebastian (Author) , Floris, Dorothea L. (Author) , Bokde, Arun L. W. (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Grigis, Antoine (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Heinz, Andreas (Author) , Brühl, Rüdiger (Author) , Martinot, Jean-Luc (Author) , Martinot, Marie-Laure Paillère (Author) , Orfanos, Dimitri Papadopoulos (Author) , Paus, Tomáš (Author) , Poustka, Luise (Author) , Fröhner, Juliane (Author) , Smolka, Michael (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Meyer-Lindenberg, Andreas (Author) , Brandeis, Daniel (Author) , Buitelaar, Jan K. (Author) , Nees, Frauke (Author) , Beckmann, Christian (Author) , Banaschewski, Tobias (Author) , Marquand, Andre F. (Author)
Format: Article (Journal)
Language:English
Published: September 2023
In: Nature neuroscience
Year: 2023, Volume: 26, Issue: 9, Pages: 1603-1612[1-19]
ISSN:1546-1726
DOI:10.1038/s41593-023-01410-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41593-023-01410-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41593-023-01410-8
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Author Notes:Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Meyer-Lindenberg, Daniel Brandeis, Jan K. Buitelaar, Frauke Nees, Christian Beckmann, Tobias Banaschewski & Andre F. Marquand
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Summary:Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.
Item Description:Online veröffentlicht: 21. August 2023
Gesehen am 11.09.2024
Physical Description:Online Resource
ISSN:1546-1726
DOI:10.1038/s41593-023-01410-8

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