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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried...

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Main Authors: Gialluisi, Alessandro (Author) , Andlauer, Till F. M. (Author) , Mirza-Schreiber, Nazanin (Author) , Moll, Kristina (Author) , Becker, Jessica (Author) , Hoffmann, Per (Author) , Ludwig, Kerstin U. (Author) , Czamara, Darina (Author) , Pourcain, Beate St (Author) , Honbolygó, Ferenc (Author) , Tóth, Dénes (Author) , Csépe, Valéria (Author) , Huguet, Guillaume (Author) , Chaix, Yves (Author) , Iannuzzi, Stephanie (Author) , Demonet, Jean-Francois (Author) , Morris, Andrew P. (Author) , Hulslander, Jacqueline (Author) , Willcutt, Erik G. (Author) , DeFries, John C. (Author) , Olson, Richard K. (Author) , Smith, Shelley D. (Author) , Pennington, Bruce F. (Author) , Vaessen, Anniek (Author) , Maurer, Urs (Author) , Lyytinen, Heikki (Author) , Peyrard-Janvid, Myriam (Author) , Leppänen, Paavo H. T. (Author) , Brandeis, Daniel (Author) , Bonte, Milene (Author) , Stein, John F. (Author) , Talcott, Joel B. (Author) , Fauchereau, Fabien (Author) , Wilcke, Arndt (Author) , Kirsten, Holger (Author) , Müller, Bent (Author) , Francks, Clyde (Author) , Bourgeron, Thomas (Author) , Monaco, Anthony P. (Author) , Ramus, Franck (Author) , Landerl, Karin (Author) , Kere, Juha (Author) , Scerri, Thomas S. (Author) , Paracchini, Silvia (Author) , Fisher, Simon E. (Author) , Schumacher, Johannes (Author) , Nöthen, Markus M. (Author) , Müller-Myhsok, Bertram (Author) , Schulte-Körne, Gerd (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Molecular psychiatry
Year: 2021, Volume: 26, Issue: 7, Pages: 3004-3017
ISSN:1476-5578
DOI:10.1038/s41380-020-00898-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41380-020-00898-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41380-020-00898-x
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Author Notes:Alessandro Gialluisi, Till F.M. Andlauer, Nazanin Mirza-Schreiber, Kristina Moll, Jessica Becker, Per Hoffmann, Kerstin U. Ludwig, Darina Czamara, Beate St Pourcain, Ferenc Honbolygó, Dénes Tóth, Valéria Csépe, Guillaume Huguet, Yves Chaix, Stephanie Iannuzzi, Jean-Francois Demonet, Andrew P. Morris, Jacqueline Hulslander, Erik G. Willcutt, John C. DeFries, Richard K. Olson, Shelley D. Smith, Bruce F. Pennington, Anniek Vaessen, Urs Maurer, Heikki Lyytinen, Myriam Peyrard-Janvid, Paavo H.T. Leppänen, Daniel Brandeis, Milene Bonte, John F. Stein, Joel B. Talcott, Fabien Fauchereau, Arndt Wilcke, Holger Kirsten, Bent Müller, Clyde Francks, Thomas Bourgeron, Anthony P. Monaco, Franck Ramus, Karin Landerl, Juha Kere, Thomas S. Scerri, Silvia Paracchini, Simon E. Fisher, Johannes Schumacher, Markus M. Nöthen, Bertram Müller-Myhsok, Gerd Schulte-Körne
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Summary:Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p  < 2.8 × 10−6) enrichment of associations at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20-25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (at pT = 0.05 in the training GWAS: OR = 1.23[1.16; 1.30] per standard deviation increase; p  = 8 × 10−13), bipolar disorder (1.53[1.44; 1.63]; p = 1 × 10−43), schizophrenia (1.36[1.28; 1.45]; p = 4 × 10−22), psychiatric cross-disorder susceptibility (1.23[1.16; 1.30]; p = 3 × 10−12), cortical thickness of the transverse temporal gyrus (0.90[0.86; 0.96]; p = 5 × 10−4), educational attainment (0.86[0.82; 0.91]; p = 2 × 10−7), and intelligence (0.72[0.68; 0.76]; p = 9 × 10−29). This study suggests an important contribution of common genetic variants to dyslexia risk, and novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Moreover, it revealed the presence of shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence.
Item Description:"Published online: 14 October 2020". - S. 3004
Gesehen am 12.09.2024
Physical Description:Online Resource
ISSN:1476-5578
DOI:10.1038/s41380-020-00898-x

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