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Structural architecture and brain network efficiency link polygenic scores to intelligence

Intelligence is highly heritable. Genome-wide association studies (GWAS) have shown that thousands of alleles contribute to variation in intelligence with small effect sizes. Polygenic scores (PGS), which combine these effects into one genetic summary measure, are increasingly used to investigate po...

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Main Authors: Genç, Erhan (Author) , Metzen, Dorothea (Author) , Fraenz, Christoph (Author) , Schlüter, Caroline (Author) , Voelkle, Manuel C. (Author) , Arning, Larissa (Author) , Streit, Fabian (Author) , Nguyen, Huu Phuc (Author) , Güntürkün, Onur (Author) , Ocklenburg, Sebastian (Author) , Kumsta, Robert (Author)
Format: Article (Journal)
Language:English
Published: June 1, 2023
In: Human brain mapping
Year: 2023, Volume: 44, Issue: 8, Pages: 3359-3376
ISSN:1097-0193
DOI:10.1002/hbm.26286
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/hbm.26286
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.26286
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Author Notes:Erhan Genç, Dorothea Metzen, Christoph Fraenz, Caroline Schlüter, Manuel C. Voelkle, Larissa Arning, Fabian Streit, Huu Phuc Nguyen, Onur Güntürkün, Sebastian Ocklenburg, Robert Kumsta
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Summary:Intelligence is highly heritable. Genome-wide association studies (GWAS) have shown that thousands of alleles contribute to variation in intelligence with small effect sizes. Polygenic scores (PGS), which combine these effects into one genetic summary measure, are increasingly used to investigate polygenic effects in independent samples. Whereas PGS explain a considerable amount of variance in intelligence, it is largely unknown how brain structure and function mediate this relationship. Here, we show that individuals with higher PGS for educational attainment and intelligence had higher scores on cognitive tests, larger surface area, and more efficient fiber connectivity derived by graph theory. Fiber network efficiency as well as the surface of brain areas partly located in parieto-frontal regions were found to mediate the relationship between PGS and cognitive performance. These findings are a crucial step forward in decoding the neurogenetic underpinnings of intelligence, as they identify specific regional networks that link polygenic predisposition to intelligence.
Item Description:Online veröffentlicht: 4. April 2023
Gesehen am 18.09.2024
Physical Description:Online Resource
ISSN:1097-0193
DOI:10.1002/hbm.26286

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