Patterns, predictors and prognostic relevance of high-grade hematotoxicity after temozolomide or temozolomide-lomustine in the CeTeG/NOA-09 trial

In the randomized phase III trial CeTeG/NOA-09, temozolomide (TMZ)/lomustine (CCNU) combination therapy was superior to TMZ in newly diagnosed MGMT methylated glioblastoma, albeit reporting more frequent hematotoxicity. Here, we analyze high grade hematotoxicity and its prognostic relevance in the t...

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Main Authors:	Weller, Johannes Michael (Author) , Schäfer, N. (Author) , Schaub, C. (Author) , Tzaridis, T. (Author) , Zeyen, T. (Author) , Schneider, M. (Author) , Potthoff, A. L. (Author) , Giordano, Frank Anton (Author) , Steinbach, J. P. (Author) , Zeiner, P. S. (Author) , Kowalski, T. (Author) , Sabel, M. (Author) , Hau, P. (Author) , Krex, D. (Author) , Grauer, O. (Author) , Goldbrunner, R. (Author) , Schnell, O. (Author) , Tabatabai, Ghazaleh (Author) , Ringel, F. (Author) , Schmidt-Graf, F. (Author) , Brehmer, Stefanie (Author) , Tonn, J. C. (Author) , Bullinger, L. (Author) , Vajkoczy, P. (Author) , Glas, M. (Author) , Vatter, H. (Author) , Herrlinger, U. (Author) , Seidel, Clemens (Author)
Format:	Article (Journal)
Language:	English
Published:	January 2023
In:	Journal of neuro-oncology Year: 2023, Volume: 161, Issue: 1, Pages: 147-153
ISSN:	1573-7373
DOI:	10.1007/s11060-022-04203-4
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-022-04203-4 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11060-022-04203-4
Author Notes:	J. Weller, N. Schäfer, C. Schaub, T. Tzaridis, T. Zeyen, M. Schneider, A.L. Potthoff, F.A. Giordano, J.P. Steinbach, P.S. Zeiner, T. Kowalski, M. Sabel, P. Hau, D. Krex, O. Grauer, R. Goldbrunner, O. Schnell, G. Tabatabai, F. Ringel, F. Schmidt-Graf, S. Brehmer, J.C. Tonn, L. Bullinger, P. Vajkoczy, M. Glas, H. Vatter, U. Herrlinger, C. Seidel