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A thalamo-preoptic pathway promotes social grooming in rodents

Social touch is an essential component of communication. Little is known about the underlying pathways and mechanisms. Here, we discovered a novel neuronal pathway from the posterior intralaminar thalamic nucleus (PIL) to the medial preoptic area (MPOA) involved in the control of social grooming. We...

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Main Authors: Keller, Dávid (Author) , Láng, Tamás (Author) , Cservenák, Melinda (Author) , Puska, Gina (Author) , Barna, János (Author) , Csillag, Veronika (Author) , Farkas, Imre (Author) , Zelena, Dóra (Author) , Dóra, Fanni (Author) , Schimmer, Stephanie (Author) , Barteczko, Lara (Author) , Usdin, Ted B. (Author) , Palkovits, Miklós (Author) , Hasan, Mazahir T. (Author) , Grinevich, Valéry (Author) , Dobolyi, Árpád (Author)
Format: Article (Journal)
Language:English
Published: November 7, 2022
In: Current biology
Year: 2022, Volume: 32, Issue: 21, Pages: 4593-4606.e8
ISSN:1879-0445
DOI:10.1016/j.cub.2022.08.062
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cub.2022.08.062
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0960982222013847
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Author Notes:Dávid Keller, Tamás Láng, Melinda Cservenák, Gina Puska, János Barna, Veronika Csillag, Imre Farkas, Dóra Zelena, Fanni Dóra, Stephanie Küppers, Lara Barteczko, Ted B. Usdin, Miklós Palkovits, Mazahir T. Hasan, Valery Grinevich, and Arpád Dobolyi
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Summary:Social touch is an essential component of communication. Little is known about the underlying pathways and mechanisms. Here, we discovered a novel neuronal pathway from the posterior intralaminar thalamic nucleus (PIL) to the medial preoptic area (MPOA) involved in the control of social grooming. We found that the neurons in the PIL and MPOA were naturally activated by physical contact between female rats and also by the chemogenetic stimulation of PIL neurons. The activity-dependent tagging of PIL neurons was performed in rats experiencing physical social contact. The chemogenetic activation of these neurons increased social grooming between familiar rats, as did the selective activation of the PIL-MPOA pathway. Neurons projecting from the PIL to the MPOA express the neuropeptide parathyroid hormone 2 (PTH2), and the central infusion of its receptor antagonist diminished social grooming. Finally, we showed a similarity in the anatomical organization of the PIL and the distribution of the PTH2 receptor in the MPOA between the rat and human brain. We propose that the discovered neuronal pathway facilitates physical contact with conspecifics.
Item Description:Online verfügbar: 15. September 2022, Artikelversion: 7. November 2022
Gesehen am 23.09.2024
Physical Description:Online Resource
ISSN:1879-0445
DOI:10.1016/j.cub.2022.08.062

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