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Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome

In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicenter co...

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Main Authors: Ladigan, Swetlana (Author) , Vangala, Deepak B. (Author) , Engel, Christoph (Author) , Bucksch, Karolin (Author) , Hueneburg, Robert (Author) , Perne, Claudia (Author) , Nattermann, Jacob (Author) , Steinke-Lange, Verena (Author) , Rahner, Nils (Author) , Schackert, Hans K. (Author) , Weitz, Jürgen (Author) , Kloor, Matthias (Author) , Kuhlkamp, Judith (Author) , Nguyen, Huu Phuc (Author) , Moeslein, Gabriela (Author) , Strassburg, Christian (Author) , Morak, Monika (Author) , Holinski-Feder, Elke (Author) , Buettner, Reinhard (Author) , Aretz, Stefan (Author) , Loeffler, Markus (Author) , Schmiegel, Wolff (Author) , Pox, Christian (Author) , Schulmann, Karsten (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: International journal of cancer
Year: 2021, Volume: 148, Issue: 1, Pages: 106-114
ISSN:1097-0215
DOI:10.1002/ijc.33294
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.33294
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33294
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Author Notes:Swetlana Ladigan-Badura, Deepak B. Vangala, Christoph Engel, Karolin Bucksch, Robert Hueneburg, Claudia Perne, Jacob Nattermann, Verena Steinke-Lange, Nils Rahner, Hans K. Schackert, Jürgen Weitz, Matthias Kloor, Judith Kuhlkamp, Huu Phuc Nguyen, Gabriela Moeslein, Christian Strassburg, Monika Morak, Elke Holinski-Feder, Reinhard Buettner, Stefan Aretz, Markus Loeffler, Wolff Schmiegel, Christian Pox, Karsten Schulmann, German Consortium for Familial Intestinal Cancer
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Summary:In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty-nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early-stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = .0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.
Item Description:"First published: 15 September 2020".- Artikel-Front door
Gesehen am 23.09.2024
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.33294

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