Cover Image

Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits: personal view

Private companies have begun offering services to allow parents undergoing in-vitro fertilisation to screen embryos for genetic risk of complex diseases, including psychiatric disorders. This procedure, called polygenic embryo screening, raises several difficult scientific and ethical issues, as dis...

Full description

Saved in:
Bibliographic Details
Main Authors: Lencz, Todd (Author) , Sabatello, Maya (Author) , Docherty, Anna (Author) , Peterson, Roseann E (Author) , Soda, Takahiro (Author) , Austin, Jehannine (Author) , Bierut, Laura (Author) , Crepaz-Keay, David (Author) , Curtis, David (Author) , Degenhardt, Franziska (Author) , Huckins, Laura (Author) , Lazaro-Munoz, Gabriel (Author) , Mattheisen, Manuel (Author) , Meiser, Bettina (Author) , Peay, Holly (Author) , Rietschel, Marcella (Author) , Walss-Bass, Consuelo (Author) , Davis, Lea K (Author)
Format: Article (Journal)
Language:English
Published: October 2022
In: The lancet. Psychiatry
Year: 2022, Volume: 9, Issue: 10, Pages: 838-844
ISSN:2215-0374
DOI:10.1016/S2215-0366(22)00157-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S2215-0366(22)00157-2
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2215036622001572
Get full text
Author Notes:Todd Lencz, Maya Sabatello, Anna Docherty, Roseann E Peterson, Takahiro Soda, Jehannine Austin, Laura Bierut, David Crepaz-Keay, David Curtis, Franziska Degenhardt, Laura Huckins, Gabriel Lazaro-Munoz, Manuel Mattheisen, Bettina Meiser, Holly Peay, Marcella Rietschel, Consuelo Walss-Bass, Lea K Davis
Description
Summary:Private companies have begun offering services to allow parents undergoing in-vitro fertilisation to screen embryos for genetic risk of complex diseases, including psychiatric disorders. This procedure, called polygenic embryo screening, raises several difficult scientific and ethical issues, as discussed in this Personal View. Polygenic embryo screening depends on the statistical properties of polygenic risk scores, which are complex and not well studied in the context of this proposed clinical application. The clinical, social, and ethical implications of polygenic embryo screening have barely been discussed among relevant stakeholders. To our knowledge, the International Society of Psychiatric Genetics is the first professional biomedical organisation to issue a statement regarding polygenic embryo screening. For the reasons discussed in this Personal View, the Society urges caution and calls for additional research and oversight on the use of polygenic embryo screening.
Item Description:Online verfügbar: 2. August 2022, Artikelversion: 15. September 2022
Gesehen am 24.09.2024
Physical Description:Online Resource
ISSN:2215-0374
DOI:10.1016/S2215-0366(22)00157-2

Similar Items