Differential expression of APO-1 on human thymocytes: implications for negative selection?
Negative selection during T cell ontogeny involves selective induction of apoptosis in thymocytes. In peripheral lymphoid cells, apoptosis may be mediated via the APO-1 pathway. Here we report that APO-1 is constitutively expressed on the vast majority of human thymocytes but down-regulated at a mat...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1994
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| In: |
European journal of immunology
Year: 1994, Volume: 24, Issue: 3, Pages: 753-758 |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.1830240339 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/eji.1830240339 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.1830240339 
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| Author Notes: | Klaus-Michael Debatin, Dorothee Süss, Peter H. Krammer |
| Summary: | Negative selection during T cell ontogeny involves selective induction of apoptosis in thymocytes. In peripheral lymphoid cells, apoptosis may be mediated via the APO-1 pathway. Here we report that APO-1 is constitutively expressed on the vast majority of human thymocytes but down-regulated at a mature stage of thymocyte development (TCRhi). This stage of development is characterized by CD28hi, CD44hi, CD69hi and up-regulation of Bcl-2 protein. We define a new thymocyte subpopulation that expresses high levels of APO-1 and intermediate levels of T cell receptor α/β (TCRim/APO-1hi). The TCRim/APO-1hi population contains a large fraction of dead cells, suggesting that the APO-1 pathway may be involved in negative selection of at least a fraction of thymocytes after intrathymic activation. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 23. November 2005 Gesehen am 24.09.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.1830240339 |