Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin
The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 1994
|
| In: |
European journal of pediatrics
Year: 1994, Jahrgang: 153, Heft: 1, Pages: 43-48 |
| ISSN: | 1432-1076 |
| DOI: | 10.1007/BF02000786 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02000786
|
| Verfasserangaben: | Verena Göbel, Hans-Georg Hoffmann, Dirk E. Müller-Wiefel, Andrea Braun, Rolf Ludwig, Karl Schärer, Klaus-Michael Debatin |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1903357470 | ||
| 003 | DE-627 | ||
| 005 | 20241205173927.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240924s1994 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF02000786 |2 doi | |
| 035 | |a (DE-627)1903357470 | ||
| 035 | |a (DE-599)KXP1903357470 | ||
| 035 | |a (OCoLC)1475313058 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Göbel, Verena |e VerfasserIn |0 (DE-588)1342973887 |0 (DE-627)1903357993 |4 aut | |
| 245 | 1 | 0 | |a Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin |c Verena Göbel, Hans-Georg Hoffmann, Dirk E. Müller-Wiefel, Andrea Braun, Rolf Ludwig, Karl Schärer, Klaus-Michael Debatin |
| 264 | 1 | |c January 1994 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.09.2024 | ||
| 520 | |a The effect of recombinant human erythropoietin (rhEPO) and interleukin 3 (IL3) on circulating haematopoietic progenitors consisting mainly of immature burst-forming-units-erythrocytes (BFU-E), was investigated in ten paediatric patients treated by regular haemodialysis. During a 30-week study rhEPO treatment resulted in a rise of median haemoglobin levels from 6.7 g/dl to >10 g/dl in all patients. Before initiating rhEPO treatment the number of circulating BFU-E in chronic renal failure patients responded to grading doses of rhEPO in vitro similar to that in control children; however, the dose-response curves were not predictive for the in vivo response to rhEPO. After an initial rise in five patients BFU-E numbers declined by week 30 of rhEPO treatment. BFU-E numbers decreased to 35% of pretreatment values. The number of granulocyte-macrophage colony forming cells (GM-CFC) also decreased during rhEPO treatment. Addition of IL3 to the culture medium containing saturating concentrations of granulocyte-macrophage colony stimulating factor did not stimulate BFU-E numbers of patients before rhEPO treatment or those of controls. However, 2 weeks after start of rhEPO treatment IL3 increased the growth of patient's BFU-E in vitro to 220% of pretreatment levels, followed by a gradual decrease of stimulation until the end of observation. These findings indicate that: (1) long-term recruitment of circulating haematopoietic progenitors during rhEPO treatment is low in children with renal anaemia; (2) rhEPO sensitivity of circulating BFU-E is not predictive for the in vivo response; (3) rhEPO treatment results in enhanced sensitivity of BFU-E to IL3. | ||
| 650 | 4 | |a Chronic renal failure Erythropoietin | |
| 650 | 4 | |a Haematopoietic progenitors | |
| 650 | 4 | |a Haemodialysis Interleukin 3 | |
| 700 | 1 | |a Hoffmann, Hans-Georg |e VerfasserIn |0 (DE-588)1342979834 |0 (DE-627)1903359171 |4 aut | |
| 700 | 1 | |a Müller-Wiefel, Dirk E. |e VerfasserIn |0 (DE-588)1027458661 |0 (DE-627)729155854 |0 (DE-576)37323161X |4 aut | |
| 700 | 1 | |a Braun, Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ludwig, Rolf |d 1948- |e VerfasserIn |0 (DE-588)1113113936 |0 (DE-627)867065257 |0 (DE-576)476854229 |4 aut | |
| 700 | 1 | |a Schärer, Karl |d 1929-2019 |e VerfasserIn |0 (DE-588)1131952650 |0 (DE-627)887311156 |0 (DE-576)488580250 |4 aut | |
| 700 | 1 | |a Debatin, Klaus-Michael |d 1952- |e VerfasserIn |0 (DE-588)109442288 |0 (DE-627)507956451 |0 (DE-576)289642809 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of pediatrics |d Berlin : Springer Science & Business Media B.V., 1975 |g 153(1994), 1, Seite 43-48 |h Online-Ressource |w (DE-627)684135361 |w (DE-600)2647723-3 |w (DE-576)367395959 |x 1432-1076 |7 nnas |a Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin |
| 773 | 1 | 8 | |g volume:153 |g year:1994 |g number:1 |g pages:43-48 |g extent:6 |a Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin |
| 856 | 4 | 0 | |u https://doi.org/10.1007/BF02000786 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20240924 | ||
| 994 | |a 1994 | ||
| 998 | |g 109442288 |a Debatin, Klaus-Michael |m 109442288:Debatin, Klaus-Michael |d 910000 |d 910500 |e 910000PD109442288 |e 910500PD109442288 |k 0/910000/ |k 1/910000/910500/ |p 7 |y j | ||
| 998 | |g 1131952650 |a Schärer, Karl |m 1131952650:Schärer, Karl |d 50000 |d 910000 |d 910500 |e 50000PS1131952650 |e 910000PS1131952650 |e 910500PS1131952650 |k 0/50000/ |k 0/910000/ |k 1/910000/910500/ |p 6 | ||
| 998 | |g 1113113936 |a Ludwig, Rolf |m 1113113936:Ludwig, Rolf |d 50000 |e 50000PL1113113936 |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1903357470 |e 4582778178 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1432-1076"],"zdb":["2647723-3"],"eki":["684135361"]},"origin":[{"publisher":"Springer Science & Business Media B.V.","dateIssuedKey":"1975","dateIssuedDisp":"1975-","publisherPlace":"Berlin ; Dordrecht"}],"part":{"extent":"6","volume":"153","text":"153(1994), 1, Seite 43-48","issue":"1","pages":"43-48","year":"1994"},"titleAlt":[{"title":"Zeitschrift für Kinderheilkunde"}],"pubHistory":["121.1975/76 -"],"language":["ger","eng"],"corporate":[{"display":"Belgian Association of Pediatric Anesthesiologists","roleDisplay":"Herausgebendes Organ","role":"isb"}],"recId":"684135361","disp":"Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietinEuropean journal of pediatrics","note":["Fortsetzung der Druck-Ausgabe","Gesehen am 29.05.12","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"European journal of pediatrics","subtitle":"official organ of the Belgian Pediatric Association","title":"European journal of pediatrics"}]}],"physDesc":[{"extent":"6 S."}],"id":{"eki":["1903357470"],"doi":["10.1007/BF02000786"]},"origin":[{"dateIssuedDisp":" January 1994","dateIssuedKey":"1994"}],"name":{"displayForm":["Verena Göbel, Hans-Georg Hoffmann, Dirk E. Müller-Wiefel, Andrea Braun, Rolf Ludwig, Karl Schärer, Klaus-Michael Debatin"]},"language":["eng"],"recId":"1903357470","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 24.09.2024"],"title":[{"title_sort":"Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin","title":"Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin"}],"person":[{"roleDisplay":"VerfasserIn","display":"Göbel, Verena","role":"aut","family":"Göbel","given":"Verena"},{"family":"Hoffmann","given":"Hans-Georg","roleDisplay":"VerfasserIn","display":"Hoffmann, Hans-Georg","role":"aut"},{"display":"Müller-Wiefel, Dirk E.","roleDisplay":"VerfasserIn","role":"aut","family":"Müller-Wiefel","given":"Dirk E."},{"display":"Braun, Andrea","roleDisplay":"VerfasserIn","role":"aut","family":"Braun","given":"Andrea"},{"role":"aut","display":"Ludwig, Rolf","roleDisplay":"VerfasserIn","given":"Rolf","family":"Ludwig"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Schärer, Karl","given":"Karl","family":"Schärer"},{"given":"Klaus-Michael","family":"Debatin","role":"aut","display":"Debatin, Klaus-Michael","roleDisplay":"VerfasserIn"}]} | ||
| SRT | |a GOEBELVERECIRCULATIN1994 | ||