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Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children

Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in...

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Bibliographic Details
Main Authors: Bäumler, Caroline Beatrix (Author) , Bonier, Thomas (Author) , Herr, Ingrid (Author) , Benner, Axel (Author) , Krammer, Peter H. (Author) , Debatin, Klaus-Michael (Author)
Format: Article (Journal)
Language:English
Published: 1 September 1996
In: Blood
Year: 1996, Volume: 88, Issue: 5, Pages: 1741-1746
ISSN:1528-0020
DOI:10.1182/blood.V88.5.1741.1741
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.V88.5.1741.1741
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120635285
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Author Notes:Caroline B. Bäumler, Thomas Bonier, Ingrid Herr, Axel Benner, Peter H. Krammer, Klaus-Michael Debatin
Description
Summary:Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-infected children. In this report we provide further evidence for a deregulated CD95 system in AIDS. CD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells. In addition, specific CD95-mediated apoptosis is enhanced in both CD4+ and CD8+ T cells. Furthermore, levels of CD95 ligand mRNA are profoundly increased. Specific T-cell receptor/CD3-triggered apoptosis in HIV-1+ children is more enhanced in CD8+ than in CD4+ T cells. Accelerated activation induced cell death of T cells could partially be inhibited by blocking anti-CD95 antibody fragments. These data suggest an involvement of the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS and may open new avenues of rational intervention strategies.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 14. Dezember 2020
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Physical Description:Online Resource
ISSN:1528-0020
DOI:10.1182/blood.V88.5.1741.1741

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