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Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07)

While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits,...

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Main Authors: Deng, Maximilian (Author) , Silva, Amanda Salviano da (Author) , Göller, Pauline C. (Author) , König, Laila (Author) , Schäfer, Henning (Author) , Maire, Cecile (Author) , Hommertgen, Adriane (Author) , Held, Thomas (Author) , Regnery, Sebastian (Author) , Eichkorn, Tanja (Author) , Stritzke, Florian (Author) , Bauer, Lukas (Author) , Schnell, Daniel (Author) , Herfarth, Klaus (Author) , Deimling, Andreas von (Author) , Krieg, Sandro (Author) , Wick, Antje (Author) , Wick, Wolfgang (Author) , Grosu, Anca (Author) , Debus, Jürgen (Author) , Sahm, Felix (Author) , Ricklefs, Franz (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: BMC cancer
Year: 2024, Volume: 24, Pages: [1]-6
ISSN:1471-2407
DOI:10.1186/s12885-024-12170-4
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-024-12170-4
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Author Notes:Maximilian Y. Deng, Amanda Salviano da Silva, Pauline Carlotta Göller, Laila König, Henning Schäfer, Cecile Maire, Adriane Lentz-Hommertgen, Thomas Held, Sebastian Regnery, Tanja Eichkorn, Florian Stritzke, Lukas Bauer, Daniel Schnell, Klaus Herfarth, Andreas von Deimling, Sandro Krieg, Antje Wick, Wolfgang Wick, Anca Grosu, Jürgen Debus, Felix Sahm and Franz Ricklefs
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Summary:While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring.
Item Description:Online veröffentlicht: 11. April 2024
Gesehen am 24.09.2024
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-024-12170-4

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