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Quality-of-life outcomes of the ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial

OBJECTIVES: To comprehensively compare quality-of-life (QoL) outcomes between open partial nephrectomy (OPN) and robot-assisted PN (RAPN) from the randomised ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial, as QoL data comparing OPN and RAPN are virtually non-existen...

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Main Authors: Sidoti Abate, Marie Angela (Author) , Menold, Hanna (Author) , Neuberger, Manuel (Author) , Kirchner, Marietta (Author) , Haney, Caelán Max (Author) , Nuhn, Philipp (Author) , Westhoff, Niklas Christian (Author) , Honeck, Patrick (Author) , Michel, Maurice Stephan (Author) , Kriegmair, Maximilian (Author) , Kowalewski, Karl-Friedrich (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: BJU international
Year: 2024, Volume: 134, Issue: 3, Pages: 434-441
ISSN:1464-410X
DOI:10.1111/bju.16407
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bju.16407
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bju.16407
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Author Notes:Marie Angela Sidoti Abate, Hanna Saskia Menold, Manuel Neuberger, Marietta Kirchner, Caelan Max Haney, Philipp Nuhn, Niklas Westhoff, Patrick Honeck, Maurice-Stephan Michel, Maximilian Christian Kriegmair and Karl-Friedrich Kowalewski
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Summary:OBJECTIVES: To comprehensively compare quality-of-life (QoL) outcomes between open partial nephrectomy (OPN) and robot-assisted PN (RAPN) from the randomised ROBOtic-assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial, as QoL data comparing OPN and RAPN are virtually non-existent, especially not from randomised controlled trials (RCTs). PATIENTS AND METHODS: The ROBOCOP II was a single-centre, open-label RCT between OPN and RAPN. The pre-planned analyses of QoL outcomes are presented. Data were analysed descriptively in a modified intention-to-treat population. RESULTS: A total of 50 patients underwent surgery. At postoperative Day 90 (POD90), there was no significant difference for the Kidney Disease Quality of Life-Short Form questionnaire score (mean [sd] OPN 72 [20] vs RAPN 76 [15], P = 0.850), while there were advantages for RAPN in the subdomains of 'Pain' (P = 0.006) and 'Physical functioning' (P = 0.011) immediately after surgery. For the European Organisation for Research and Treatment of Cancer quality of life questionnaire 30-item core there were overall advantages directly after surgery (mean [sd] score OPN 63 [20] vs RAPN 75 [17], P = 0.031), as well as for the subdomains 'Fatigue' (P = 0.026), 'Pain' (P = 0.002) and 'Constipation' (P = 0.045) but no differences at POD90. There were no differences for the EuroQoL five Dimensions five Levels questionnaire at POD90 (mean [sd] score OPN 70 [22] vs RAPN 72 [17], P = 1.0) or at any other time point. Finally, no significant differences were found for the overall Convalescence and Recovery Evaluation questionnaire score at POD90 (mean [sd] OPN 84 [13] vs RAPN 86 [10], P = 0.818) but less pain in the RAPN group (P = 0.017) directly after surgery. CONCLUSIONS: Pain and physical functioning as subdomains of QoL are improved after RAPN compared to OPN in the early postoperative course, while there are no differences anymore after 3 months.
Item Description:Zuerst veröffentlicht: 24. Mai 2024
Gesehen am 26.09.2024
Physical Description:Online Resource
ISSN:1464-410X
DOI:10.1111/bju.16407

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