Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats

The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often hypertensive and/or obese or diabetic. Indeed, there is evidence on sex differences in the development of HF. Hence, we studied cardiovascular performance depen...

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Main Authors: Kovács, Árpád (Author) , Zhazykbayeva, Saltanat (Author) , Herwig, Melissa (Author) , Fülöp, Gábor Á. (Author) , Csípő, Tamás (Author) , Oláh, Nikolett (Author) , Hassoun, Roua (Author) , Budde, Heidi (Author) , Osman, Hersh (Author) , Kaçmaz, Mustafa (Author) , Jaquet, Kornelia (Author) , Priksz, Dániel (Author) , Juhász, Béla (Author) , Akın, Ibrahim (Author) , Papp, Zoltán (Author) , Schmidt, Wolfgang E. (Author) , Mügge, Andreas (Author) , El-Battrawy, Ibrahim (Author) , Tóth, Attila (Author) , Hamdani, Nazha (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: GeroScience
Year: 2024, Volume: 46, Issue: 5, Pages: 4543-4561
ISSN:2509-2723
DOI:10.1007/s11357-024-01160-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11357-024-01160-w
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Author Notes:Árpád Kovács, Saltanat Zhazykbayeva, Melissa Herwig, Gábor Á. Fülöp, Tamás Csípő, Nikolett Oláh, Roua Hassoun, Heidi Budde, Hersh Osman, Mustafa Kaçmaz, Kornelia Jaquet, Dániel Priksz, Béla Juhász, Ibrahim Akin, Zoltán Papp, Wolfgang E. Schmidt, Andreas Mügge, Ibrahim El-Battrawy, Attila Tóth, Nazha Hamdani
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Summary:The prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women often hypertensive and/or obese or diabetic. Indeed, there is evidence on sex differences in the development of HF. Hence, we studied cardiovascular performance dependent on sex and age as well as pathomechanisms on a cellular and molecular level.
Item Description:Online veröffentlicht: 24. April 2024
Gesehen am 27.09.2024
Physical Description:Online Resource
ISSN:2509-2723
DOI:10.1007/s11357-024-01160-w