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Ionic mechanisms of disopyramide prolonging action potential duration in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with short QT syndrome type 1

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<p>Short QT syndrome (SQTS) is associated with tachyarrhythmias and sudden cardiac death. So far, only quinidine has been demonstrated to be effective in patients with SQTS type 1(SQTS1). The aim of this study was to investigate the mechanisms of disopyramide underlying its antiarrhythmic effe...

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Main Authors: Lan, Huan (Author) , Xu, Qiang (Author) , El-Battrawy, Ibrahim (Author) , Zhong, Rujia (Author) , Li, Xin (Author) , Lang, Siegfried (Author) , Cyganek, Lukas (Author) , Borggrefe, Martin (Author) , Zhou, Xiao-Bo (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 12 October 2020
In: Frontiers in pharmacology
Year: 2020, Volume: 11, Pages: 1-11
ISSN:1663-9812
DOI:10.3389/fphar.2020.554422
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fphar.2020.554422
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.554422/full
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Author Notes:Huan Lan, Qiang Xu, Ibrahim El-Battrawy, Rujia Zhong, Xin Li, Siegfried Lang, Lukas Cyganek, Martin Borggrefe, Xiaobo Zhou and Ibrahim Akin
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Genetic ablation of TASK-1 (tandem of P domains in a weak inward rectifying K+ channel-related acid-sensitive K+ channel-1) (K2P3.1) K+ channels suppresses atrial fibrillation and... by Schmidt, Constanze (Author) , Wiedmann, Felix Tobias (Author) , El-Battrawy, Ibrahim (Author) , Lan, Huan (Author) , Szabó, Gábor (Author) , Lang, Siegfried (Author) , Rapti, Kleopatra (Author) , Ratte, Antonius (Author) , Karck, Matthias (Author) , Akın, Ibrahim (Author) , Borggrefe, Martin (Author) , Zhou, Xiao-Bo (Author) , Katus, Hugo (Author) , Thomas, Dierk (Author) ,


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