Stress-induced sensitization of insula activation predicts alcohol craving and alcohol use in alcohol use disorder: archival report
Background - Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder. However, the neurobiological processes underlying their interaction are not well understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 February 2024
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| In: |
Biological psychiatry
Year: 2024, Volume: 95, Issue: 3, Pages: 245-255 |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/j.biopsych.2023.08.024 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.biopsych.2023.08.024 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S000632232301555X 
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| Author Notes: | Patrick Bach, Judith Zaiser, Sina Zimmermann, Tatjana Gessner, Sabine Hoffmann, Sarah Gerhardt, Oksana Berhe, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Heike Tost, Bernd Lenz, Sabine Vollstädt-Klein, Jan Stallkamp, Clemens Kirschbaum, and Falk Kiefer |
| Summary: | Background - Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder. However, the neurobiological processes underlying their interaction are not well understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial stress on neural cue reactivity and addictive behaviors. - Methods - Neural alcohol cue reactivity was assessed in 91 individuals with alcohol use disorder using a validated functional magnetic resonance imaging (fMRI) task. Activation patterns were measured twice, at baseline and during a second fMRI session, prior to which participants were assigned to psychosocial stress (experimental condition) or a matched control condition or physical exercise (control conditions). Together with fMRI data, alcohol craving and cortisol levels were assessed, and alcohol use data were collected during a 12-month follow-up. Analyses tested the effects of psychosocial stress on neural cue reactivity and associations with cortisol levels, craving, and alcohol use. - Results - Compared with both control conditions, psychosocial stress elicited higher alcohol cue-induced activation in the left anterior insula (familywise error-corrected p < .05) and a stress- and cue-specific dynamic increase in insula activation over time (F22,968 = 2.143, p = .007), which was predicted by higher cortisol levels during the experimental intervention (r = 0.310, false discovery rate-corrected p = .016). Cue-induced insula activation was positively correlated with alcohol craving during fMRI (r = 0.262, false discovery rate-corrected p = .032) and alcohol use during follow-up (r = 0.218, false discovery rate-corrected p = .046). - Conclusions - Results indicate a stress-induced sensitization of cue-induced activation in the left insula as a neurobiological correlate of the effects of psychosocial stress on alcohol craving and alcohol use in alcohol use disorder, which likely reflects changes in salience attribution and goal-directed behavior. |
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| Item Description: | Online verfügbar: 9. September 2023, Artikelversion: 22. December 2023 Gesehen am 01.10.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/j.biopsych.2023.08.024 |