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Stress-induced sensitization of insula activation predicts alcohol craving and alcohol use in alcohol use disorder: archival report

Background - Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder. However, the neurobiological processes underlying their interaction are not well understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial...

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Hauptverfasser: Bach, Patrick (VerfasserIn) , Zaiser, Judith (VerfasserIn) , Vetter, Sina (VerfasserIn) , Gessner, Tatjana (VerfasserIn) , Hoffmann, Sabine (VerfasserIn) , Gerhardt, Sarah (VerfasserIn) , Berhe, Oksana (VerfasserIn) , Bekier, Nina Kim (VerfasserIn) , Abel, Martin (VerfasserIn) , Radler, Philipp (VerfasserIn) , Langejürgen, Jens (VerfasserIn) , Tost, Heike (VerfasserIn) , Lenz, Bernd (VerfasserIn) , Vollstädt-Klein, Sabine (VerfasserIn) , Stallkamp, Jan (VerfasserIn) , Kirschbaum, Clemens (VerfasserIn) , Kiefer, Falk (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 February 2024
In: Biological psychiatry
Year: 2024, Jahrgang: 95, Heft: 3, Pages: 245-255
ISSN:1873-2402
DOI:10.1016/j.biopsych.2023.08.024
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.biopsych.2023.08.024
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S000632232301555X
Volltext
Verfasserangaben:Patrick Bach, Judith Zaiser, Sina Zimmermann, Tatjana Gessner, Sabine Hoffmann, Sarah Gerhardt, Oksana Berhe, Nina Kim Bekier, Martin Abel, Philipp Radler, Jens Langejürgen, Heike Tost, Bernd Lenz, Sabine Vollstädt-Klein, Jan Stallkamp, Clemens Kirschbaum, and Falk Kiefer
Beschreibung
Zusammenfassung:Background - Stress and alcohol cues trigger alcohol consumption and relapse in alcohol use disorder. However, the neurobiological processes underlying their interaction are not well understood. Thus, we conducted a randomized, controlled neuroimaging study to investigate the effects of psychosocial stress on neural cue reactivity and addictive behaviors. - Methods - Neural alcohol cue reactivity was assessed in 91 individuals with alcohol use disorder using a validated functional magnetic resonance imaging (fMRI) task. Activation patterns were measured twice, at baseline and during a second fMRI session, prior to which participants were assigned to psychosocial stress (experimental condition) or a matched control condition or physical exercise (control conditions). Together with fMRI data, alcohol craving and cortisol levels were assessed, and alcohol use data were collected during a 12-month follow-up. Analyses tested the effects of psychosocial stress on neural cue reactivity and associations with cortisol levels, craving, and alcohol use. - Results - Compared with both control conditions, psychosocial stress elicited higher alcohol cue-induced activation in the left anterior insula (familywise error-corrected p < .05) and a stress- and cue-specific dynamic increase in insula activation over time (F22,968 = 2.143, p = .007), which was predicted by higher cortisol levels during the experimental intervention (r = 0.310, false discovery rate-corrected p = .016). Cue-induced insula activation was positively correlated with alcohol craving during fMRI (r = 0.262, false discovery rate-corrected p = .032) and alcohol use during follow-up (r = 0.218, false discovery rate-corrected p = .046). - Conclusions - Results indicate a stress-induced sensitization of cue-induced activation in the left insula as a neurobiological correlate of the effects of psychosocial stress on alcohol craving and alcohol use in alcohol use disorder, which likely reflects changes in salience attribution and goal-directed behavior.
Beschreibung:Online verfügbar: 9. September 2023, Artikelversion: 22. December 2023
Gesehen am 01.10.2024
Beschreibung:Online Resource
ISSN:1873-2402
DOI:10.1016/j.biopsych.2023.08.024

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