Optimizing ATR inhibition and Cisplatin Synergy in Ewing Sarcoma
EWSR1::FLI1-mediated dysregulation of cellular machinery opens up potential new avenues for Ewing sarcoma treatment. A recent study demonstrates that pharmacologic ATR kinase inhibition dramatically synergizes with low-dose cisplatin through EWSR1::FLI1-dependent rewiring of transcription, DNA repai...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 August 2024
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| In: |
Clinical cancer research
Year: 2024, Jahrgang: 30, Heft: 16, Pages: 3358-3360 |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-24-1047 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-24-1047
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| Verfasserangaben: | Shunya Ohmura and Thomas G.P. Grünewald |
| Zusammenfassung: | EWSR1::FLI1-mediated dysregulation of cellular machinery opens up potential new avenues for Ewing sarcoma treatment. A recent study demonstrates that pharmacologic ATR kinase inhibition dramatically synergizes with low-dose cisplatin through EWSR1::FLI1-dependent rewiring of transcription, DNA repair, and translation machinery, which could maximize the therapeutic window of the combinatory therapy. |
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| Beschreibung: | Gesehen am 09.10.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-24-1047 |