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Comparative study of the antiproliferative activity of heterometallic carbene gold(I)-platinum(II) and gold(I)-palladium(II) complexes in cancer cell lines

The stepwise, one-pot synthesis of heterobimetallic carbene gold(I) platinum(II) complexes from readily available starting materials is presented. The protecting group free methodology is based on the graduated nucleophilicities of aliphatic and aromatic amines as linkers between both metal centers....

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Hauptverfasser: Dietl, Martin C. (VerfasserIn) , Maag, Melina (VerfasserIn) , Ber, Sophia (VerfasserIn) , Rominger, Frank (VerfasserIn) , Rudolph, Matthias (VerfasserIn) , Caligiuri, Isabella (VerfasserIn) , Andele, Pacome K. (VerfasserIn) , Mkhalid, Ibraheem A. I. (VerfasserIn) , Rizzolio, Flavio (VerfasserIn) , Nogara, Pablo A. (VerfasserIn) , Orian, Laura (VerfasserIn) , Scattolin, Thomas (VerfasserIn) , Hashmi, A. Stephen K. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 Aug 2024
In: Chemical science
Year: 2024, Jahrgang: 15, Heft: 37, Pages: 15291-15298
ISSN:2041-6539
DOI:10.1039/D4SC04585H
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1039/D4SC04585H
Verlag, kostenfrei, Volltext: https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc04585h
Volltext
Verfasserangaben:Martin C. Dietl, Melina Maag, Sophia Ber, Frank Rominger, Matthias Rudolph, Isabella Caligiuri, Pacome K. Andele, Ibraheem A.I. Mkhalid, Flavio Rizzolio, Pablo A. Nogara, Laura Orian, Thomas Scattolin and A. Stephen K. Hashmi
Beschreibung
Zusammenfassung:The stepwise, one-pot synthesis of heterobimetallic carbene gold(I) platinum(II) complexes from readily available starting materials is presented. The protecting group free methodology is based on the graduated nucleophilicities of aliphatic and aromatic amines as linkers between both metal centers. This enables the selective, sequential installation of the metal fragments. In addition, the obtained complexes were tested as potential anticancer agents and directly compared to their gold(I) palladium(II) counterparts.
Beschreibung:Gesehen am 14.10.2024
Beschreibung:Online Resource
ISSN:2041-6539
DOI:10.1039/D4SC04585H

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