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Radiosynthesis of stable 198Au-nanoparticles by neutron activation of αvβ3-specific AuNPs for therapy of tumor angiogenesis

This paper reports on the development of stable tumor-specific gold nanoparticles (AuNPs) activated by neutron irradiation as a therapeutic option for the treatment of cancer with high tumor angiogenesis. The AuNPs were designed with different mono- or dithiol-ligands and decorated with different am...

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Main Authors: Davarci, Güllü (Author) , Wängler, Carmen (Author) , Eberhardt, Klaus (Author) , Geppert, Christopher (Author) , Schirrmacher, Ralf (Author) , Freudenberg, Robert (Author) , Pretze, Marc (Author) , Wängler, Björn (Author)
Format: Article (Journal)
Language:English
Published: 30 November 2023
In: Pharmaceuticals
Year: 2023, Volume: 16, Issue: 12, Pages: 1-22
ISSN:1424-8247
DOI:10.3390/ph16121670
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ph16121670
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1424-8247/16/12/1670
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Author Notes:Güllü Davarci, Carmen Wängler, Klaus Eberhardt, Christopher Geppert, Ralf Schirrmacher, Robert Freudenberg, Marc Pretze and Björn Wängler
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Summary:This paper reports on the development of stable tumor-specific gold nanoparticles (AuNPs) activated by neutron irradiation as a therapeutic option for the treatment of cancer with high tumor angiogenesis. The AuNPs were designed with different mono- or dithiol-ligands and decorated with different amounts of Arg-Gly-Asp (RGD) peptides as a tumor-targeting vector for αvβ3 integrin, which is overexpressed in tissues with high tumor angiogenesis. The AuNPs were evaluated for avidity in vitro and showed favorable properties with respect to tumor cell accumulation. Furthermore, the therapeutic properties of the [198Au]AuNPs were evaluated in vitro on U87MG cells in terms of cell survival, suggesting that these [198Au]AuNPs are a useful basis for future therapeutic concepts.
Item Description:Die Zahl "198" ist im Titel hochgestellt, der Buchstabe "v" und die Ziffer "3" sind tiefgestellt
Gesehen am 15.10.2024
Physical Description:Online Resource
ISSN:1424-8247
DOI:10.3390/ph16121670

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