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Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021

Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are...

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Main Authors: Geier, Johannes (Author) , Schubert, Steffen (Author) , Rieker-Schwienbacher, Juliane (Author) , Brans, Richard (Author) , Weisshaar, Elke (Author) , Kränke, Birger (Author) , Brockow, Knut (Author) , Ruёff, Franziska (Author) , Recke, Andreas (Author) , Uter, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: May 2024
In: Contact dermatitis
Year: 2024, Volume: 90, Issue: 5, Pages: 470-478
ISSN:1600-0536
DOI:10.1111/cod.14493
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/cod.14493
Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1111%2Fcod.14493&DestApp=DOI&SrcAppSID=EUW1ED0C50D8Hb6hoez360dlMJ5wL&SrcJTitle=CONTACT+DERMATITIS&DestDOIRegistrantName=Wiley+%28Blackwell+Publishing%29
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Author Notes:Johannes Geier, Steffen Schubert, Juliane Rieker-Schwienbacher, Richard Brans, Elke Weisshaar, Birger Kraenke, Knut Brockow, Franziska Ruёff, Andreas Recke, Wolfgang Uter for the IVDK
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Summary:Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series.Objective: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients.Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2012-2021.Results: Positive reactions to FM I (FM II) declined from 9.1% (4.7%) in 2012 to 4.6% (3.0%) in 2021. Full breakdown tests were performed in 24% (FM I) and 31% (FM II), respectively, of the mix-positive patients. From this data, frequencies of sensitization to the 14 single fragrances of FM I and FM II were calculated. For the majority, a decline was noted from 2012/2013 to 2020/2021, for oakmoss absolute 1.9%-0.8% and for HICC 1.8%-0.9%.Conclusion: EU Commission Regulation 2017/1410 was an effective measure. However, our data have some limitations, possibly causing underestimation of sensitization frequencies to fragrances.
Item Description:Gesehen am 22.10.2024
Physical Description:Online Resource
ISSN:1600-0536
DOI:10.1111/cod.14493

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