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Cardiac sympathetic nervous activity during myocardial ischemia, reperfusion and ventricular fibrillation in the dog: effects of intravenous lidocaine

In 12 open-chest dogs, cardiac sympathetic nervous activity (CSNA) was recorded before and after occlusion of the left anterior descending coronary artery as well as during reperfusion and ventricular fibrillation (VF). In 7 control animals, CSNA did not significantly differ from preocclusion levels...

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Bibliographic Details
Main Authors: Aidonidis, Isaac (Author) , Brachmann, Johannes (Author) , Seller, Horst (Author) , Dembowsky, Klaus (Author) , Czachurski, Jürgen (Author) , Kübler, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 1992
In: Cardiology
Year: 2008, Volume: 80, Issue: 3-4, Pages: 196-204
ISSN:1421-9751
DOI:10.1159/000175003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000175003
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Author Notes:Isaac Aidonidis, Johannes Brachmann, Horst Seller, Klaus Dembowsky, Jürgen Czachurski, Wolfgang Kübler
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Summary:In 12 open-chest dogs, cardiac sympathetic nervous activity (CSNA) was recorded before and after occlusion of the left anterior descending coronary artery as well as during reperfusion and ventricular fibrillation (VF). In 7 control animals, CSNA did not significantly differ from preocclusion levels when determined 20 min after occlusion (+3.5 ± 1.5%, mean ± SEM) and up to 15 min following reperfusion (+1.5 ± 0.6%). However, VF was associated with a potential increase in CSNA by 106 ± 15.5%(p < 0.001). The effect of lidocaine (6 mg/kg) on cardiac sympathetic tone was examined in 5 additional animals. Lidocaine reduced control CSNA by 23 ± 4.7% (p < 0.001); subsequent ischemia and reperfusion did not substantially change the level of preocclusion activity. CSNA decreased significantly also during VF (52 ± 4.2%, p < 0.001). In conclusion, efferent CSNA was slightly altered in the course of acute myocardial ischemia and reperfusion, but significantly increased during VF. Lidocaine produced marked attenuation of CSNA in anesthetized dogs.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 12. November 2008
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Physical Description:Online Resource
ISSN:1421-9751
DOI:10.1159/000175003

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