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Implications for driving based on the risk of seizures after ischaemic stroke

Background In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. - Methods We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence o...

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Main Authors: Schubert, Kai Michael (Author) , Bicciato, Giulio (Author) , Sinka, Lucia (Author) , Abraira, Laura (Author) , Santamarina, Estevo (Author) , Álvarez-Sabín, José (Author) , Ferreira-Atuesta, Carolina (Author) , Katan, Mira (Author) , Scherrer, Natalie (Author) , Terziev, Robert (Author) , Döhler, Nico (Author) , Erdélyi-Canavese, Barbara (Author) , Felbecker, Ansgar (Author) , Siebel, Philip (Author) , Winklehner, Michael (Author) , Oertzen, Tim J. von (Author) , Wagner, Judith N. (Author) , Gigli, Gian Luigi (Author) , Nilo, Annacarmen (Author) , Janes, Francesco (Author) , Merlino, Giovanni (Author) , Valente, Mariarosaria (Author) , Zafra-Sierra, María Paula (Author) , Mayor-Romero, Luis Carlos (Author) , Conrad, Julian (Author) , Evers, S. (Author) , Lochner, Piergiorgio (Author) , Roell, Frauke (Author) , Brigo, Francesco (Author) , Bentes, Carla (Author) , Peralta, Rita (Author) , Melo, Teresa Pinho e (Author) , Keezer, Mark R. (Author) , Duncan, John Sidney (Author) , Sander, Josemir W. (Author) , Tettenborn, Barbara (Author) , Koepp, Matthias (Author) , Galovic, Marian (Author)
Format: Article (Journal)
Language:English
Published: August 16, 2024
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2024, Volume: 95, Issue: 9, Pages: 833-837
ISSN:1468-330X
DOI:10.1136/jnnp-2024-333505
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1136/jnnp-2024-333505
Verlag, kostenfrei, Volltext: https://jnnp.bmj.com/content/95/9/833
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Author Notes:Kai Michael Schubert, Giulio Bicciato, Lucia Sinka, Laura Abraira, Estevo Santamarina, José Álvarez-Sabín, Carolina Ferreira-Atuesta, Mira Katan, Natalie Scherrer, Robert Terziev, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Michael Winklehner, Tim J. von Oertzen, Judith N. Wagner, Gian Luigi Gigli, Annacarmen Nilo, Francesco Janes, Giovanni Merlino, Mariarosaria Valente, María Paula Zafra-Sierra, Luis Carlos Mayor-Romero, Julian Conrad, S. Evers, Piergiorgio Lochner, Frauke Roell, Francesco Brigo, Carla Bentes, Rita Peralta, Teresa Pinho e Melo, Mark R. Keezer, John Sidney Duncan, Josemir W. Sander, Barbara Tettenborn, Matthias Koepp, Marian Galovic
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Summary:Background In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. - Methods We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and no prior seizures. We calculated the Chance of Occurrence of Seizure in the next Year (COSY) according to the SeLECT2.0 prognostic model. We considered COSY<20% safe for private and <2% for professional driving, aligning with commonly used cut-offs. - Results Seizure risks in the next year were mainly influenced by the baseline risk-stratified according to the SeLECT2.0 score and, to a lesser extent, by the poststroke seizure-free interval (SFI). Those without acute symptomatic seizures (SeLECT2.0 0-6 points) had low COSY (0.7%-11%) immediately after stroke, not requiring an SFI. In stroke survivors with acute symptomatic seizures (SeLECT2.0 3-13 points), COSY after a 3-month SFI ranged from 2% to 92%, showing substantial interindividual variability. Stroke survivors with acute symptomatic status epilepticus (SeLECT2.0 7-13 points) had the highest risk (14%-92%). - Conclusions Personalised prognostic models, such as SeLECT2.0, may offer better guidance for poststroke driving decisions than generic SFIs. Our findings provide practical tools, including a smartphone-based or web-based application, to assess seizure risks and determine appropriate SFIs for safe driving.
Item Description:Zu diesem Artikel gibt es Supplementary Material
Online veröffentlicht: 15. Mai, 2024
Gesehen am 23.10.2024
Physical Description:Online Resource
ISSN:1468-330X
DOI:10.1136/jnnp-2024-333505

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