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High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer

Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (B...

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Main Authors: Göbel, Andy (Author) , Rachner, Tilman Daniel (Author) , Hoffmann, Oliver (Author) , Klotz, Daniel Martin (Author) , Kasimir-Bauer, Sabine (Author) , Kimmig, Rainer (Author) , Hofbauer, Lorenz (Author) , Bittner, Ann-Kathrin (Author)
Format: Article (Journal)
Language:English
Published: June 2024
In: Archives of gynecology and obstetrics
Year: 2024, Volume: 309, Issue: 6, Pages: 2789-2798
ISSN:1432-0711
DOI:10.1007/s00404-024-07434-0
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00404-024-07434-0
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00404-024-07434-0
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Author Notes:Andy Göbel, Tilman D. Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C. Hofbauer, Ann-Kathrin Bittner
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Summary:Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (BC), high intratumoral LRG-1 protein expression levels are associated with reduced survival. In this study, we assessed serum levels of LRG-1 in patients with early BC and investigated its correlation with the presence of disseminated tumor cells (DTCs) in the bone marrow and survival outcomes.
Item Description:Online veröffentlicht am 28. Februar 2024
Gesehen am 04.11.2024
Physical Description:Online Resource
ISSN:1432-0711
DOI:10.1007/s00404-024-07434-0

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