Medication adherence and persistence in children and adolescents with attention deficit hyperactivity disorder (ADHD): a systematic review and qualitative update: review
Low medication-adherence and persistence may reduce the effectiveness of ADHD-medication. This preregistered systematic review (PROSPERO CRD42020218654) on medication-adherence and persistence in children and adolescents with ADHD focuses on clinically relevant questions and extends previous reviews...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2025
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| In: |
European child & adolescent psychiatry
Year: 2025, Volume: 34, Issue: 3, Pages: 867-882 |
| ISSN: | 1435-165X |
| DOI: | 10.1007/s00787-024-02538-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00787-024-02538-z
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| Author Notes: | Maite Ferrin, Alexander Häge, James Swanson, Kirstie H.T.W. Wong, Ralf W. Dittmann, Tobias Banaschewski, David Coghill, Paramala J. Santosh, Marcel Romanos, Emily Simonoff, Jan K. Buitelaar on behalf of The European ADHD Guidelines Group (EAGG) |
| Summary: | Low medication-adherence and persistence may reduce the effectiveness of ADHD-medication. This preregistered systematic review (PROSPERO CRD42020218654) on medication-adherence and persistence in children and adolescents with ADHD focuses on clinically relevant questions and extends previous reviews by including additional studies. We included a total of n = 66 studies. There was a lack of consistency in the measurement of adherence/persistence between studies. Pooling the medication possession ratios (MPR) and using the most common adherence definition (MPR ≥ 80%) indicated that only 22.9% of participants had good adherence at 12-month follow-up. Treatment persistence on medication measured by treatment duration during a 12-month follow-up averaged 170 days (5.6 months). Our findings indicate that medication-adherence and persistence among youth with ADHD are generally poor and have not changed in recent years. Clinicians need to be aware that various factors may contribute to poor adherence/persistence and that long-acting stimulants and psychoeducational programs may help to improve adherence/persistence. However, the evidence to whether better adherence/persistence contributes to better long-term outcomes is limited and requires further research. |
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| Item Description: | Online veröffentlicht: 6. August 2024 Mitglieder der European ADHD Guidelines Group (EAGG): Dieter Baeyens, (Belgium); Tobias Banaschewski, (Germany); Sven Bölte, (Sweden); Daniel Brandeis, (Germany and Switzerland); Jan K. Buitelaar, (Netherlands); Sara Carucci, (Italy); David Coghill, (Australia); Cortese, Samuele (United Kingdom) (EAGG chair); David Daley, (United Kingdom); Manfred Döpfner, (Germany); Maite Ferrin, (United Kingdom); Cedric Galera, (France); Hollis, Chris (United Kingdom); Martin Holtmann, (Germany); Peter Nagy, (Hungary); Purper-Ouakil, Diane (France); J. Antoni Ramos-Quiroga, (Spain); Marcel Romanos, (Germany); Paramala J. Santosh, (United Kingdom); Emily Simonoff, (United Kingdom); Edmund Sonuga-Barke, (United Kingdom); Cesar A. Soutullo, (United States); Hans-Christoph Steinhausen, (Switzerland); Anita Thapar, (United Kingdom); Barbara J. Van den Hoofdakker, (The Netherlands); Saskia Van der Oord, (Belgium); Ian C.K. Wong, (Hong Kong). Dieter Baeyens, Tobias Banaschewski, Sven Bölte, Daniel Brandeis, Jan K. Buitelaar, Sara Carucci, David Coghill, Cortese, Samuele David Daley, Manfred Döpfner, Maite Ferrin, Cedric Galera, Hollis, Chris Martin Holtmann, Peter Nagy, Purper-Ouakil, Diane J. Antoni Ramos-Quiroga, Marcel Romanos, Paramala J. Santosh, Emily Simonoff, Edmund Sonuga-Barke, Cesar A. Soutullo, Hans-Christoph Steinhausen, Anita Thapar, Barbara J. Van den Hoofdakker, Saskia Van der Oord, Ian C. K. Wong Gesehen am 29.09.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1435-165X |
| DOI: | 10.1007/s00787-024-02538-z |