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A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study

Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1-3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures that have a remarkable risk of postoperative morbidity and mortality, the 5-year survival r...

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Main Authors: Niger, Monica (Author) , Nichetti, Federico (Author) , Fornaro, Lorenzo (Author) , Pircher, Chiara (Author) , Morano, Federica (Author) , Palermo, Federica (Author) , Rimassa, Lorenza (Author) , Pressiani, Tiziana (Author) , Berardi, Rossana (Author) , Gardini, Andrea Casadei (Author) , Sperti, Elisa (Author) , Salvatore, Lisa (Author) , Melisi, Davide (Author) , Bergamo, Francesca (Author) , Siena, Salvatore (Author) , Mosconi, Stefania (Author) , Longarini, Raffaella (Author) , Arcangeli, Giuseppina (Author) , Corallo, Salvatore (Author) , Delliponti, Laura (Author) , Tamberi, Stefano (Author) , Fea, Elena (Author) , Brandi, Giovanni (Author) , Rapposelli, Ilario Giovanni (Author) , Salati, Massimiliano (Author) , Baili, Paolo (Author) , Miceli, Rosalba (Author) , Ljevar, Silva (Author) , Cavallo, Ilaria (Author) , Sottotetti, Elisa (Author) , Martinetti, Antonia (Author) , Busset, Michele Droz Dit (Author) , Sposito, Carlo (Author) , Di Bartolomeo, Maria (Author) , Pietrantonio, Filippo (Author) , de Braud, Filippo (Author) , Mazzaferro, Vincenzo (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: BMC cancer
Year: 2024, Volume: 24, Issue: 1, Pages: [1]-10
ISSN:1471-2407
DOI:10.1186/s12885-024-12225-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-024-12225-6
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Author Notes:Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi, Raffaella Longarini, Giuseppina Arcangeli, Salvatore Corallo, Laura Delliponti, Stefano Tamberi, Elena Fea, Giovanni Brandi, Ilario Giovanni Rapposelli, Massimiliano Salati, Paolo Baili, Rosalba Miceli, Silva Ljevar, Ilaria Cavallo, Elisa Sottotetti, Antonia Martinetti, Michele Droz Dit Busset, Carlo Sposito, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud and Vincenzo Mazzaferro
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Summary:Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1-3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures that have a remarkable risk of postoperative morbidity and mortality, the 5-year survival rate after radical surgery (R0) is 20-40% and recurrence rates are up to ~ 75%(4-6). Up to ~ 40% of patients relapse within 12 months after resection, and half of these patient will recur systemically(4-6). There is no standard of care for neoadjuvant chemotherapy (NAC) in resectable BTC, but retrospective reports suggest its potential benefit (7, 8).
Item Description:Online veröffentlicht: 8. April 2024
Gesehen am 06.11.2024
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-024-12225-6

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