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Dropout from exercise trials among cancer survivor: an individual patient data meta-analysis from the POLARIS study

Introduction The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of par...

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Main Authors: Western, Benedikte (Author) , Ivarsson, Andreas (Author) , Vistad, Ingvild (Author) , Demmelmaier, Ingrid (Author) , Aaronson, Neil K. (Author) , Radcliffe, Gillian (Author) , van Beurden, Marc (Author) , Bohus, Martin (Author) , Courneya, Kerry S. (Author) , Daley, Amanda J. (Author) , Galvão, Daniel A. (Author) , Garrod, Rachel (Author) , Goedendorp, Martine M. (Author) , Griffith, Kathleen A. (Author) , van Harten, Wim H. (Author) , Hayes, Sandi C. (Author) , Herrero-Roman, Fernando (Author) , Hiensch, Anouk E. (Author) , Irwin, Melinda L. (Author) , James, Erica (Author) , Kenkhuis, Marlou-Floor (Author) , Kersten, Marie José (Author) , Knoop, Hans (Author) , Lucia, Alejandro (Author) , May, Anne M. (Author) , McConnachie, Alex (Author) , van Mechelen, Willem (Author) , Mutrie, Nanette (Author) , Newton, Robert U. (Author) , Nollet, Frans (Author) , Oldenburg, Hester S. (Author) , Plotnikoff, Ron (Author) , Schmidt, Martina (Author) , Schmitz, Katie H. (Author) , Schulz, Karl-Heinz (Author) , Short, Camille E. (Author) , Sonke, Gabe S. (Author) , Steindorf, Karen (Author) , Stuiver, Martijn M. (Author) , Taaffe, Dennis R. (Author) , Thorsen, Lene (Author) , Velthuis, Miranda J. (Author) , Wenzel, Jennifer (Author) , Winters-Stone, Kerri M. (Author) , Wiskemann, Joachim (Author) , Berntsen, Sveinung (Author) , Buffart, Laurien M. (Author)
Format: Article (Journal)
Language:English
Published: 09 February 2024
In: Scandinavian journal of medicine & science in sports
Year: 2024, Volume: 34, Issue: 2, Pages: 1-10
ISSN:1600-0838
DOI:10.1111/sms.14575
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/sms.14575
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/sms.14575
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Author Notes:Benedikte Western, Andreas Ivarsson, Ingvild Vistad, Ingrid Demmelmaier, Neil K. Aaronson, Gillian Radcliffe, Marc van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Rachel Garrod, Martine M. Goedendorp, Kathleen A. Griffith, Wim H. van Harten, Sandi C. Hayes, Fernando Herrero-Roman, Anouk E. Hiensch, Melinda L. Irwin, Erica James, Marlou-Floor Kenkhuis, Marie José Kersten, Hans Knoop, Alejandro Lucia, Anne M. May, Alex McConnachie, Willem van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Ron Plotnikoff, Martina E. Schmidt, Katie H. Schmitz, Karl-Heinz Schulz, Camille E. Short, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Sveinung Berntsen, Laurien M. Buffart
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Summary:Introduction The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients without metastatic disease randomized to an exercise arm were included. Harmonized studies included a pre and a posttest, and participants were classified as dropouts when missing all assessments at the post-intervention test. Subgroups were identified with a conditional inference tree. Results Overall, 9.6% of the participants dropped out. Five subgroups were identified in the conditional inference tree based on four significant associations with dropout. Most dropout was observed for participants with BMI >28.4 kg/m2, performing supervised resistance or unsupervised mixed exercise (19.8% dropout) or had low-medium education and performed aerobic or supervised mixed exercise (13.5%). The lowest dropout was found for participants with BMI >28.4 kg/m2 and high education performing aerobic or supervised mixed exercise (5.1%), and participants with BMI ≤28.4 kg/m2 exercising during (5.2%) or post (9.5%) treatment. Conclusions There are several systematic differences between cancer survivors completing and dropping out from exercise trials, possibly affecting the external validity of exercise effects.
Item Description:Gesehen am 11.11.2024
Physical Description:Online Resource
ISSN:1600-0838
DOI:10.1111/sms.14575

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