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Observed-to-expected lung-area-to-head-circumference ratio on ultrasound examination vs total fetal lung volume on magnetic resonance imaging in prediction of survival in fetuses with left-sided diaphragmatic hernia

ABSTRACT Objective To assess and compare the value of antenatally determined observed-to-expected (O/E) lung-area-to-head-circumference ratio (LHR) on ultrasound examination vs O/E total fetal lung volume (TFLV) on magnetic resonance imaging (MRI) examination to predict postnatal survival of fetuses...

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Main Authors: Seeger genannt Dütemeyer, Vivien (Author) , Schaible, Thomas (Author) , Badr, D. A. (Author) , Cordier, A.-G. (Author) , Weis, Meike (Author) , Perez Ortiz, Alba (Author) , Carriere, D. (Author) , Cannie, M. M. (Author) , Vuckovic, A. (Author) , Persico, N. (Author) , Cavallaro, G. (Author) , Houfflin-Debarge, V. (Author) , Carreras, E. (Author) , Benachi, A. (Author) , Jani, J. C. (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Ultrasound in obstetrics & gynecology
Year: 2024, Volume: 64, Issue: 3, Pages: 354-361
ISSN:1469-0705
DOI:10.1002/uog.29096
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/uog.29096
Verlag, kostenfrei, Volltext: https://obgyn.onlinelibrary.wiley.com/doi/10.1002/uog.29096
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Author Notes:V. Dütemeyer, T. Schaible, D.A. Badr, A.-G. Cordier, M. Weis, A. Perez-Ortiz, D. Carriere, M.M. Cannie, A. Vuckovic, N. Persico, G. Cavallaro, V. Houfflin-Debarge, E. Carreras, A. Benachi and J.C. Jani
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Summary:ABSTRACT Objective To assess and compare the value of antenatally determined observed-to-expected (O/E) lung-area-to-head-circumference ratio (LHR) on ultrasound examination vs O/E total fetal lung volume (TFLV) on magnetic resonance imaging (MRI) examination to predict postnatal survival of fetuses with isolated, expectantly managed left-sided congenital diaphragmatic hernia (CDH). Methods This was a multicenter retrospective study including all consecutive fetuses with isolated CDH that were managed expectantly in Mannheim, Germany, and in five other European centers, that underwent at least one ultrasound examination for measurement of O/E-LHR and one MRI scan for measurement of O/E-TFLV during pregnancy. All MRI data were centralized, and lung volumes were measured by two experienced operators blinded to the pre- and postnatal data. Multiple logistic regression analyses were performed to examine the effect on survival at hospital discharge of various perinatal variables, including the center of management. In left-sided CDH with intrathoracic herniation of the liver, receiver-operating-characteristics (ROC) curves were constructed separately for cases from Mannheim and the other five European centers and were used to compare O/E-TFLV and O/E-LHR in the prediction of postnatal survival. Results From Mannheim, 309 patients were included with a median gestational age (GA) at ultrasound examination of 29.6 (range, 19.7?39.1)?weeks and median GA at MRI examination of 31.1 (range, 18.0?39.9)?weeks. From the other five European centers, 116 patients were included with a median GA at ultrasound examination of 26.7 (range, 20.6?37.6)?weeks and median GA at MRI examination of 27.7 (range, 21.3?37.9)?weeks. Regression analysis demonstrated that the survival rates at discharge were lower in left-sided CDH (odds ratio (OR), 0.349 (95%?CI, 0.133?0.918), P?=?0.033) and those with intrathoracic liver (OR, 0.297 (95%?CI, 0.141?0.628), P?=?0.001), and higher with increasing O/E-TFLV (OR, 1.123 (95%?CI, 1.079?1.170), P?
Item Description:Online veröffentlicht: 12. August 2024
Gesehen am 13.11.2024
Physical Description:Online Resource
ISSN:1469-0705
DOI:10.1002/uog.29096

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