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The impact of Body Mass Index on the mortality of myocardial infarction patients with nonobstructive coronary arteries

Objectives Myocardial infarction without significant stenosis or occlusion of the coronary arteries carries a high risk of recurrent major adverse cardiovascular events and poor prognosis. This study aimed to investigate the association between body mass index and outcomes in patients with a suspect...

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Main Authors: Dong, Chaohui (Author) , Kacmaz, Mustafa (Author) , Schlettert, Clara (Author) , Abumayyaleh, Mohammad S. A. (Author) , Akın, Ibrahim (Author) , Hemetsberger, Rayyan (Author) , Mügge, Andreas (Author) , Aweimer, Assem (Author) , Hamdani, Nazha (Author) , El-Battrawy, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Clinical cardiology
Year: 2024, Volume: 47, Issue: 9, Pages: 1-10
ISSN:1932-8737
DOI:10.1002/clc.70013
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/clc.70013
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.70013
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Author Notes:Chaohui Dong, Mustafa Kacmaz, Clara Schlettert, Mohammad Abumayyaleh, Ibrahim Akin, Rayyan Hemetsberger, Andreas Mügge, Assem Aweimer, Nazha Hamdani, Ibrahim El-Battrawy
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Summary:Objectives Myocardial infarction without significant stenosis or occlusion of the coronary arteries carries a high risk of recurrent major adverse cardiovascular events and poor prognosis. This study aimed to investigate the association between body mass index and outcomes in patients with a suspected myocardial infarction with nonobstructive coronary artery disease (MINOCA). Methods Patients were recruited at Bergmannsheil University Hospital from January 2010 to April 2021. The primary outcomes were in-hospital and long-term mortality. Secondary outcomes consisted of adverse events during hospitalization and during follow-up. Results A total of 373 patients were included in the study, with a mean follow-up time of 6.2 years. The patients were divided into different BMI groups: < 25 kg/m² (n = 121), 25−30 kg/m² (n = 140), and > 30 kg/m² (n = 112). In-hospital mortality was 1.7% versus 2.1% versus 4.5% (p = 0.368). However, long-term mortality tended to be higher in the < 25 kg/m² group compared to the 25−30 and > 30 kg/m² groups (log-rank p = 0.067). Subgroup analysis using Kaplan−Meier analysis showed a higher rate of cardiac cause of death in the < 25 kg/m² group compared to the 25−30 and > 30 kg/m² groups: 5.7% versus 1.1% versus 0.0% (log-rank p = 0.042). No significant differences were observed in other adverse events between the different BMI groups during hospitalization and long-term follow-up. Conclusions Patients with a BMI < 25 kg/m² who experience a suspected myocardial infarction without significant coronary artery disease may have higher all-cause mortality and cardiovascular cause of death. However, further data are needed to confirm these findings.
Item Description:Online veröffentlicht: 11. September 2024
Gesehen am 13.11.2024
Physical Description:Online Resource
ISSN:1932-8737
DOI:10.1002/clc.70013

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