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Incidence and risk assessment of capsular contracture in breast cancer patients following post-mastectomy radiotherapy and implant-based reconstruction

Our study aims to identify the risk factors and dosimetry characteristics associated with capsular contracture. Methods: We retrospectively analyzed 118 women with breast cancer who underwent PMRT following an IBR between 2010 and 2022. Patients were treated with PMRT of 50.0-50.4 Gy in 25-28 fracti...

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Main Authors: Vinsensia, Maria (Author) , Schaub, Riccarda (Author) , Meixner, Eva (Author) , Hoegen-Saßmannshausen, Philipp (Author) , Arians, Nathalie (Author) , Forster, Tobias (Author) , Hoeltgen, Line (Author) , Köhler, Clara (Author) , Uzun-Lang, Kristin (Author) , Batista, Vania (Author) , König, Laila (Author) , Zivanovic, Oliver (Author) , Hennigs, André (Author) , Golatta, Michael (Author) , Heil, Jörg (Author) , Debus, Jürgen (Author) , Hörner-Rieber, Juliane (Author)
Format: Article (Journal)
Language:English
Published: 7 January 2024
In: Cancers
Year: 2024, Volume: 16, Issue: 2, Pages: 1-15
ISSN:2072-6694
DOI:10.3390/cancers16020265
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16020265
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/2/265
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Author Notes:Maria Vinsensia, Riccarda Schaub, Eva Meixner, Philipp Hoegen, Nathalie Arians, Tobias Forster, Line Hoeltgen, Clara Köhler, Kristin Uzun-Lang, Vania Batista, Laila König, Oliver Zivanovic, Andre Hennigs, Michael Golatta, Jörg Heil, Jürgen Debus, Juliane Hörner-Rieber
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Summary:Our study aims to identify the risk factors and dosimetry characteristics associated with capsular contracture. Methods: We retrospectively analyzed 118 women with breast cancer who underwent PMRT following an IBR between 2010 and 2022. Patients were treated with PMRT of 50.0-50.4 Gy in 25-28 fractions. Capsular contracture was categorized according to the Baker Classification for Reconstructed Breasts. Results: After a median follow-up of 22 months, the incidence of clinically relevant capsular contracture (Baker III-IV) was 22.9%. Overall, capsular contracture (Baker I-IV) occurred in 56 patients (47.5%) after a median of 9 months after PMRT. The rate of reconstruction failure/implant loss was 25.4%. In the univariate analysis, postoperative complications (prolonged pain, prolonged wound healing, seroma and swelling) and regional nodal involvement were associated with higher rates of capsular contracture (p = 0.017, OR: 2.5, 95% CI: 1.2-5.3 and p = 0.031, respectively). None of the analyzed dosimetric factors or the implant position were associated with a higher risk for capsular contracture. Conclusion: Postoperative complications and regional nodal involvement were associated with an increased risk of capsular contracture following breast reconstruction and PMRT, while none of the analyzed dosimetric factors were linked to a higher incidence. Additional studies are needed to identify further potential risk factors.
Item Description:Gesehen am 14.11.2024
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers16020265

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