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SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

Hormone-activated proteolysis is a recurring theme of plant hormone signaling mechanisms. In strigolactone signaling, the enzyme receptor DWARF14 (D14) and an F-box protein, MORE AXILLARY GROWTH2 (MAX2), mark SUPPRESSOR OF MAX2 1-LIKE (SMXL) family proteins SMXL6, SMXL7, and SMXL8 for rapid degradat...

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Main Authors: Li, Qingtian (Author) , Yu, Haiyang (Author) , Chang, Wenwen (Author) , Chang, Sunhyun (Author) , Guzmán, Michael (Author) , Faure, Lionel (Author) , Wallner, Eva-Sophie (Author) , Yan, Heqin (Author) , Greb, Thomas (Author) , Wang, Lei (Author) , Yao, Ruifeng (Author) , Nelson, David C. (Author)
Format: Article (Journal)
Language:English
Published: 1 April 2024
In: Molecular plant
Year: 2024, Volume: 17, Issue: 4, Pages: 631-647
ISSN:1752-9867
DOI:10.1016/j.molp.2024.03.006
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.molp.2024.03.006
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1674205224000790
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Author Notes:Qingtian Li, Haiyang Yu, Wenwen Chang, Sunhyun Chang, Michael Guzmán, Lionel Faure, Eva-Sophie Wallner, Heqin Yan, Thomas Greb, Lei Wang, Ruifeng Yao and David C. Nelson
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Summary:Hormone-activated proteolysis is a recurring theme of plant hormone signaling mechanisms. In strigolactone signaling, the enzyme receptor DWARF14 (D14) and an F-box protein, MORE AXILLARY GROWTH2 (MAX2), mark SUPPRESSOR OF MAX2 1-LIKE (SMXL) family proteins SMXL6, SMXL7, and SMXL8 for rapid degradation. Removal of these transcriptional corepressors initiates downstream growth responses. The homologous proteins SMXL3, SMXL4, and SMXL5, however, are resistant to MAX2-mediated degradation. We discovered that the smxl4 smxl5 mutant has enhanced responses to strigolactone. SMXL5 attenuates strigolactone signaling by interfering with AtD14-SMXL7 interactions. SMXL5 interacts with AtD14 and SMXL7, providing two possible ways to inhibit SMXL7 degradation. SMXL5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression (EAR) motif, which typically mediates interactions with the TOPLESS family of transcriptional corepressors. However, we found that loss of the EAR motif reduces SMXL5-SMXL7 interactions and the attenuation of strigolactone signaling by SMXL5. We hypothesize that integration of SMXL5 into heteromeric SMXL complexes reduces the susceptibility of SMXL6/7/8 proteins to strigolactone-activated degradation and that the EAR motif promotes the formation or stability of these complexes. This mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXL5 expression or translation.
Item Description:Online verfügbar 12 March 2024, Version des Artikels 28 March 2024
Gesehen am 20.11.2024
Physical Description:Online Resource
ISSN:1752-9867
DOI:10.1016/j.molp.2024.03.006

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