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Left ventricular diastolic dysfunction in patients with heart failure with mildly reduced ejection fraction

Objective - This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm. - Background - Data regarding the prognostic impact of DD in patients with HFmrEF is...

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Main Authors: Abel, Noah (Author) , Schupp, Tobias (Author) , Schmitt, Alexander (Author) , Reinhardt, Marielen (Author) , Lau, Felix (Author) , Weidner, Kathrin (Author) , Ayoub, Mohamed (Author) , Mashayekhi, Kambis (Author) , Akın, Ibrahim (Author) , Behnes, Michael (Author)
Format: Article (Journal)
Language:English
Published: 1 November 2024
In: International journal of cardiology
Year: 2024, Volume: 414, Pages: 1-7
ISSN:1874-1754
DOI:10.1016/j.ijcard.2024.132386
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2024.132386
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527324010088
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Author Notes:Noah Abel, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Felix Lau, Kathrin Weidner, Mohamed Ayoub, Kambis Mashayekhi, Ibrahim Akin, Michael Behnes
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Summary:Objective - This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm. - Background - Data regarding the prognostic impact of DD in patients with HFmrEF is limited. - Methods - From 2016 to 2022, all patients hospitalized with HFmrEF (i.e., left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution. Patients with DD were compared to patients without (i.e., non-DD), further risk stratification was performed according to the severity of DD. The primary endpoint was all-cause mortality at 30 months (interquartile range (IQR) 15-61 months), key secondary endpoint was rehospitalization for worsening HF. - Results - From a total of 1154 patients (median age 68 years, 68% males) hospitalized with HFmrEF, concomitant DD was present in 72% (grade I: 56%, grade II: 14%, grade III: 2%). Patients with DD were older (71 years vs. 65 years; p = 0.001) and presented with higher rates of cardiovascular comorbidities. The presence of DD was not associated with the risk of long-term all-cause mortality (adjusted HR = 0.815; 95% CI 0.612-1.085; p = 0.161) or HF-related rehospitalization (adjusted HR = 0.736; 95% CI 0.442-1.225; p = 0.238). Furthermore, the outcome did not differ in patients with more advanced stages of DD. - Conclusion - DD is commonly prevalent in patients with HFmrEF, but not associated with long-term prognosis.
Item Description:Online verfügbar: 28. Juli 2024, Artikelversion: 3. August 2024
Gesehen am 25.11.2024
Physical Description:Online Resource
ISSN:1874-1754
DOI:10.1016/j.ijcard.2024.132386

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