Left ventricular diastolic dysfunction in patients with heart failure with mildly reduced ejection fraction
Objective - This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm. - Background - Data regarding the prognostic impact of DD in patients with HFmrEF is...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 November 2024
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| In: |
International journal of cardiology
Year: 2024, Jahrgang: 414, Pages: 1-7 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2024.132386 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2024.132386 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527324010088 
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| Verfasserangaben: | Noah Abel, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Felix Lau, Kathrin Weidner, Mohamed Ayoub, Kambis Mashayekhi, Ibrahim Akin, Michael Behnes |
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| 245 | 1 | 0 | |a Left ventricular diastolic dysfunction in patients with heart failure with mildly reduced ejection fraction |c Noah Abel, Tobias Schupp, Alexander Schmitt, Marielen Reinhardt, Felix Lau, Kathrin Weidner, Mohamed Ayoub, Kambis Mashayekhi, Ibrahim Akin, Michael Behnes |
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| 520 | |a Objective - This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm. - Background - Data regarding the prognostic impact of DD in patients with HFmrEF is limited. - Methods - From 2016 to 2022, all patients hospitalized with HFmrEF (i.e., left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution. Patients with DD were compared to patients without (i.e., non-DD), further risk stratification was performed according to the severity of DD. The primary endpoint was all-cause mortality at 30 months (interquartile range (IQR) 15-61 months), key secondary endpoint was rehospitalization for worsening HF. - Results - From a total of 1154 patients (median age 68 years, 68% males) hospitalized with HFmrEF, concomitant DD was present in 72% (grade I: 56%, grade II: 14%, grade III: 2%). Patients with DD were older (71 years vs. 65 years; p = 0.001) and presented with higher rates of cardiovascular comorbidities. The presence of DD was not associated with the risk of long-term all-cause mortality (adjusted HR = 0.815; 95% CI 0.612-1.085; p = 0.161) or HF-related rehospitalization (adjusted HR = 0.736; 95% CI 0.442-1.225; p = 0.238). Furthermore, the outcome did not differ in patients with more advanced stages of DD. - Conclusion - DD is commonly prevalent in patients with HFmrEF, but not associated with long-term prognosis. | ||
| 650 | 4 | |a Diastolic dysfunction | |
| 650 | 4 | |a Heart failure with mildly reduced ejection fraction | |
| 650 | 4 | |a HFmrEF | |
| 650 | 4 | |a Mortality | |
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