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Helium ion therapy for advanced juvenile nasopharyngeal angiofibroma

Helium ion therapy (HRT) is a promising modality for the treatment of pediatric tumors and those located close to critical structures due to the favorable biophysical properties of helium ions. This in silico study aimed to explore the potential benefits of HRT in advanced juvenile nasopharyngeal an...

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Main Authors: Hoeltgen, Line (Author) , Meixner, Eva (Author) , Hoegen-Saßmannshausen, Philipp (Author) , Kim, Ji-Young (Author) , Deng, Maximilian (Author) , Seidensaal, Katharina (Author) , Held, Thomas (Author) , Herfarth, Klaus (Author) , Haberer, Thomas (Author) , Debus, Jürgen (Author) , Mairani, Andrea (Author) , Harrabi, Semi B. (Author) , Tessonnier, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 24 May 2024
In: Cancers
Year: 2024, Volume: 16, Issue: 11, Pages: 1-17
ISSN:2072-6694
DOI:10.3390/cancers16111993
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16111993
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/11/1993
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Author Notes:Line Hoeltgen, Eva Meixner, Philipp Hoegen-Saßmannshausen, Ji-Young Kim, Maximilian Deng, Katharina Seidensaal, Thomas Held, Klaus Herfarth, Thomas Haberer, Jürgen Debus, Andrea Mairani, Semi Harrabi and Thomas Tessonnier
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Summary:Helium ion therapy (HRT) is a promising modality for the treatment of pediatric tumors and those located close to critical structures due to the favorable biophysical properties of helium ions. This in silico study aimed to explore the potential benefits of HRT in advanced juvenile nasopharyngeal angiofibroma (JNA) compared to proton therapy (PRT). We assessed 11 consecutive patients previously treated with PRT for JNA in a definitive or postoperative setting with a relative biological effectiveness (RBE) weighted dose of 45 Gy (RBE) in 25 fractions at the Heidelberg Ion-Beam Therapy Center. HRT plans were designed retrospectively for dosimetric comparisons and risk assessments of radiation-induced complications. HRT led to enhanced target coverage in all patients, along with sparing of critical organs at risk, including a reduction in the brain integral dose by approximately 27%. In terms of estimated risks of radiation-induced complications, HRT led to a reduction in ocular toxicity, cataract development, xerostomia, tinnitus, alopecia and delayed recall. Similarly, HRT led to reduced estimated risks of radiation-induced secondary neoplasms, with a mean excess absolute risk reduction of approximately 30% for secondary CNS malignancies. HRT is a promising modality for advanced JNA, with the potential for enhanced sparing of healthy tissue and thus reduced radiation-induced acute and long-term complications.
Item Description:Gesehen am 26.11.2024
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers16111993

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