Cover Image

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Show other versions (1)

Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose starvation is not well understood. Here we show that the m...

Full description

Saved in:
Bibliographic Details
Main Authors: Levy, Tal (Author) , Völtzke, Kai Philipp (Author) , Hruby, Laura (Author) , Alasad, Khawla (Author) , Bas, Zülal (Author) , Snæbjörnsson, Marteinn (Author) , Marciano, Ran (Author) , Scharov, Katerina (Author) , Planque, Mélanie (Author) , Vriens, Kim (Author) , Christen, Stefan (Author) , Funk, Cornelius M. (Author) , Haßiepen, Christina Olivia (Author) , Kahler, Alisa (Author) , Heider, Beate (Author) , Picard, Daniel (Author) , Lim, Jonathan (Author) , Stefanski, Anja (Author) , Bendrin, Katja (Author) , Vargas-Toscano, Andres (Author) , Kahlert, Ulf D. (Author) , Stühler, Kai (Author) , Remke, Marc (Author) , Elkabets, Moshe (Author) , Grünewald, Thomas G. P. (Author) , Reichert, Andreas (Author) , Fendt, Sarah-Maria (Author) , Schulze, Almut (Author) , Reifenberger, Guido (Author) , Rotblat, Barak (Author) , Leprivier, Gabriel (Author)
Format: Article (Journal)
Language:English
Published: 14 May 2024
In: Nature Communications
Year: 2024, Volume: 15, Pages: 1-20
ISSN:2041-1723
DOI:10.1038/s41467-024-48386-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-48386-y
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-48386-y
Get full text
Author Notes:Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K.M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat & Gabriel Leprivier
Description
Summary:Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose starvation is not well understood. Here we show that the mTORC1 effectors eukaryotic initiation factor 4E binding proteins 1/2 (4EBP1/2) confer protection to mammalian cells and budding yeast under glucose starvation. Mechanistically, 4EBP1/2 promote NADPH homeostasis by preventing NADPH-consuming fatty acid synthesis via translational repression of Acetyl-CoA Carboxylase 1 (ACC1), thereby mitigating oxidative stress. This has important relevance for cancer, as oncogene-transformed cells and glioma cells exploit the 4EBP1/2 regulation of ACC1 expression and redox balance to combat energetic stress, thereby supporting transformation and tumorigenicity in vitro and in vivo. Clinically, high EIF4EBP1 expression is associated with poor outcomes in several cancer types. Our data reveal that the mTORC1-4EBP1/2 axis provokes a metabolic switch essential for survival during glucose starvation which is exploited by transformed and tumor cells.
Item Description:Gesehen am 27.11.2024
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-024-48386-y

Similar Items