RNA-binding proteins in cardiovascular biology and disease: the beat goes on
Cardiac development and function are becoming increasingly well understood from different angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the importance of the post-transcriptional landscape of cardiac biology largely remains to be uncovered, building on the fou...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2024
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| In: |
Nature reviews. Cardiology
Year: 2024, Volume: 21, Issue: 6, Pages: 361-378 |
| ISSN: | 1759-5010 |
| DOI: | 10.1038/s41569-023-00958-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41569-023-00958-z Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41569-023-00958-z 
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| Author Notes: | Mirko Völkers, Thomas Preiss, Matthias W. Hentze |
| Summary: | Cardiac development and function are becoming increasingly well understood from different angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the importance of the post-transcriptional landscape of cardiac biology largely remains to be uncovered, building on the foundation of a few existing paradigms. The discovery during the past decade of hundreds of additional RNA-binding proteins in mammalian cells and organs, including the heart, is expected to accelerate progress and has raised intriguing possibilities for better understanding the intricacies of cardiac development, metabolism and adaptive alterations. In this Review, we discuss the progress and new concepts on RNA-binding proteins and RNA biology and appraise them in the context of common cardiovascular clinical conditions, from cell and organ-wide perspectives. We also discuss how a better understanding of cardiac RNA-binding proteins can fill crucial knowledge gaps in cardiology and might pave the way to developing better treatments to reduce cardiovascular morbidity and mortality. |
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| Item Description: | Online veröffentlicht: 2. Januar 2024 Gesehen am 28.11.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1759-5010 |
| DOI: | 10.1038/s41569-023-00958-z |