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Drugst: One - a plug-and-play solution for online systems medicine and network-based drug repurposing

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidat...

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Main Authors: Maier, Andreas (Author) , Hartung, Michael (Author) , Abovsky, Mark (Author) , Adamowicz, Klaudia (Author) , Bader, Gary D (Author) , Baier, Sylvie (Author) , Blumenthal, David B (Author) , Chen, Jing (Author) , Elkjaer, Maria L (Author) , Garcia-Hernandez, Carlos (Author) , Helmy, Mohamed (Author) , Hoffmann, Markus (Author) , Jurisica, Igor (Author) , Kotlyar, Max (Author) , Lazareva, Olga (Author) , Levi, Hagai (Author) , List, Markus (Author) , Lobentanzer, Sebastian (Author) , Loscalzo, Joseph (Author) , Malod-Dognin, Noel (Author) , Manz, Quirin (Author) , Matschinske, Julian (Author) , Mee, Miles (Author) , Oubounyt, Mhaned (Author) , Pastrello, Chiara (Author) , Pico, Alexander R (Author) , Pillich, Rudolf T (Author) , Poschenrieder, Julian M (Author) , Pratt, Dexter (Author) , Pržulj, Nataša (Author) , Sadegh, Sepideh (Author) , Sáez Rodríguez, Julio (Author) , Sarkar, Suryadipto (Author) , Shaked, Gideon (Author) , Shamir, Ron (Author) , Trummer, Nico (Author) , Turhan, Ugur (Author) , Wang, Rui-Sheng (Author) , Zolotareva, Olga (Author) , Baumbach, Jan (Author)
Format: Article (Journal)
Language:English
Published: 5 July 2024
In: Nucleic acids research
Year: 2024, Volume: 52, Issue: W1, Pages: W481-W488
ISSN:1362-4962
DOI:10.1093/nar/gkae388
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/nar/gkae388
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Author Notes:Andreas Maier, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D. Bader, Sylvie Baier, David B. Blumenthal, Jing Chen, Maria L. Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-Dognin, Quirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R. Pico, Rudolf T. Pillich, Julian M. Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui-Sheng Wang, Olga Zolotareva and Jan Baumbach
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Summary:In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.
Item Description:Veröffentlicht: 23 May 2024
Gesehen am 09.12.2024
Physical Description:Online Resource
ISSN:1362-4962
DOI:10.1093/nar/gkae388

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