When size matters: a novel compact Cas12a variant for in vivo genome editing
A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors.
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 17, 2024
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| In: |
PLoS biology
Year: 2024, Volume: 22, Issue: 7, Pages: 1-4 |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.3002637 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pbio.3002637 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002637 
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| Author Notes: | Felix Bubeck, Dirk Grimm |
| Summary: | A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors. |
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| Item Description: | Gesehen am 12.12.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1545-7885 |
| DOI: | 10.1371/journal.pbio.3002637 |