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Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING

The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-stranded DNA (dsDNA) links environmental stimuli and inflammation. We hypothesized that nit...

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Main Authors: Markel, Moritz (Author) , Tse, Wai Hei (Author) , De Leon, Nolan (Author) , Jank, Marietta (Author) , Albrechtsen, Jaida (Author) , Kahnamoui Zadeh, Shana (Author) , Patel, Daywin (Author) , Ozturk, Arzu (Author) , Lacher, Martin (Author) , Wagner, Richard (Author) , Keijzer, Richard (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: Pediatric research
Year: 2024, Pages: 1-7
ISSN:1530-0447
DOI:10.1038/s41390-024-03277-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41390-024-03277-2
Verlag, lizenzpflichtig, Volltext: http://www.nature.com/articles/s41390-024-03277-2
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Author Notes:Moritz Markel, Wai Hei Tse, Nolan De Leon, Marietta Jank, Jaida Albrechtsen, Shana Kahnamoui Zadeh, Daywin Patel, Arzu Ozturk, Martin Lacher, Richard Wagner and Richard Keijzer
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Summary:The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-stranded DNA (dsDNA) links environmental stimuli and inflammation. We hypothesized that nitrofen exposure alters cGAS and STING in human bronchial epithelial cells and fetal rat lungs.
Item Description:Online veröffentlicht: 30. Mai 2024
Gesehen am 17.12.2024
Physical Description:Online Resource
ISSN:1530-0447
DOI:10.1038/s41390-024-03277-2

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