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What do German Molecular Tumor Boards recommend in patients with PIK3CA-mutated tumors?: Launch and first results from the German Transsectoral Molecular Tumor Board exchange platform Deutschland

Introduction: Comprehensive molecular tumor profiling is widely used in the management of patients with cancer. Molecular tumor boards devise treatment strategies based on testing results. In this setting, the Transsectoral Molecular Tumor Board exchange platform Deutschland (TEAM-D) aims to drive p...

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Main Authors: Pretzell, Ina (Author) , Desuki, Alexander (Author) , Bleckmann, Annalen (Author) , Loges, Sonja (Author) , Reinacher-Schick, Anke (Author) , Westphalen, C. Benedikt (Author) , Lange, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: September 2024
In: Oncology research and treatment
Year: 2024, Volume: 47, Issue: 9, Pages: 410-419
ISSN:2296-5262
DOI:10.1159/000539217
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000539217
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Author Notes:Ina Pretzell, Alexander Desuki, Annalen Bleckmann, Sonja Loges, Anke Reinacher-Schick, C. Benedikt Westphalen, Sebastian Lange, on behalf of TEAM-D Participants
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Summary:Introduction: Comprehensive molecular tumor profiling is widely used in the management of patients with cancer. Molecular tumor boards devise treatment strategies based on testing results. In this setting, the Transsectoral Molecular Tumor Board exchange platform Deutschland (TEAM-D) aims to drive peer-to-peer exchange to connect experts in the field. Methods: During the first virtual TEAM-D meeting, participants from 16 German universities and 5 nonacademic institutions discussed five cases with PIK3CA hotspot mutations. Furthermore, an illustrative case vignette was presented. Results: Overall, German caregivers show restraint in administering off-label PIK3CA inhibitor and favor clinical trials in this setting. Conclusion: In the setting of precision oncology, TEAM-D enables virtual case discussion across the different sectors of the German healthcare system. Based on the example of PIK3CA hotspot mutations, TEAM-D demonstrated the value of integrating knowledge from different healthcare professionals.
Item Description:Online veröffentlicht: 7. May 2024
Gesehen am 17.12.2024
Physical Description:Online Resource
ISSN:2296-5262
DOI:10.1159/000539217

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