Genetic prediction of micronutrient levels and the risk of colorectal polyps: a mendelian randomization study
Objective - Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2024
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| In: |
Clinical nutrition
Year: 2024, Volume: 43, Issue: 6, Pages: 1405-1413 |
| ISSN: | 1532-1983 |
| DOI: | 10.1016/j.clnu.2024.04.019 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.clnu.2024.04.019 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0261561424001262 
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| Author Notes: | Siyao Lv, Yunyi Ding, Junli Huang, Yixin He, Ruijie Xie, Xiaohong Shi, Wei Ye |
| Summary: | Objective - Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP. - Methods - Summary statistics for CP (n = 463,010) were obtained from pan-European genome-wide association studies, and instrumental variables for 13 micronutrients were screened from published genome-wide association studies (GWAS). After selecting suitable instrumental variables, we performed a two-sample MR study, deploying sensitivity analyses to judge heterogeneity and pleiotropy, using inverse variance weighted methods as our primary estimation tool. - Results - Our study identified that a genetic predisposition to elevated toenail and circulating selenium or serum β-carotene concentrations lowers the risk of CP occurrence. However, no statistically significant association was observed between the other 11 micronutrients and the risk of CP. - Conclusion - The study findings provide evidence that the micronutrient selenium and β-carotene may confer protective effects against the development of CP. |
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| Item Description: | Gesehen am 08.01.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1532-1983 |
| DOI: | 10.1016/j.clnu.2024.04.019 |